HOME >> BIOLOGY >> NEWS
Penn researchers discover pathway that eliminates genetic defects in red blood cells

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have discovered a unique molecular pathway that detects and selectively eliminates defective messenger RNAs from red blood cells. Other such pathways known as surveillance pathways operate in a more general way, in many cell types. Knowing how this specific surveillance system works can help researchers better understand hereditary diseases, in this case, thalassemia, a form of anemia, which is the most common genetic disorder worldwide.

The results appear in the most recent issue of Nature Structural and Molecular Biology.

Cells have developed surveillance mechanisms that identify and destroy abnormal RNAs. Mistakes in a cells reading of RNA into protein can lead to the production of an abnormal protein, and this can result in abnormal cell function or death.

The form of thalassemia studied by the Penn group is caused by a mutation that allows the cells ribosome to read too far, making a protein that is too long. Thalassemias result from an underproduction of hemoglobin proteins the oxygen carrying molecule in blood hence the anemia. The particular mutation they study is carried by millions of people in Southeast Asia and is a major a cause of fetal loss and disease in adults. Specifically in this study they show how far the ribosome has to read into the RNA to trigger destabilization of the protein.

Several surveillance pathways have been identified over the last few years that recognize specific types of mutations in RNAs. For example, the most well-described pathway is one that recognizes nonsense mutations that result in an RNA that makes a protein that is too short. Duchenes muscular dystrophy and cystic fibrosis are examples of hereditary diseases that result from nonsense mutations.

We describe a surveillance pathway that targets RNA that is only found in red blood cells, says senior author Stephen A. Liebhaber, MD, Profe
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
1-Aug-2007


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. U-M researchers find family of on switches that cause prostate cancer
6. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
7. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
8. MGH researchers confirm that bone marrow restores fertility in female mice
9. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
10. U-M researchers identify gene involved in breast cancer
11. Drug protects brain cells in Huntingtons disease model, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2020)... ... March 24, 2020 , ... PathSensors Inc, a Baltimore ... detect the Novel SARS Coronavirus (SARS-CoV-2), the causal agent for the coronavirus disease ... validation data on the new SARS-CoV-2 product will be available June 2020. , ...
(Date:3/19/2020)... (PRWEB) , ... March 17, 2020 , ... ... tools for characterizing microbiome populations down to the strain level, recently unveiled a ... Shoreline Wave amplicon kit contains the same innovative amplification capabilities as the Shoreline ...
(Date:3/13/2020)... ... March 13, 2020 , ... Acumed LLC today announced that ... distributor of the Louisville-based company’s orthobiologics portfolio. Under the terms of the agreement, ... calcium phosphate-based bone allograft (Trabexus) and calcium phosphate-based biocement (Fortera). Vivorte will continue ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... ... March 10, 2020 , ... Lifecycle Biotechnologies announced today that is ... to be used as a biopharmaceutical and biotechnology production and development campus. Lifecycle is ... well as its production and development hub. The company expects to relocate from Fort ...
(Date:3/2/2020)... , ... March 02, 2020 , ... McBee, Moore and ... 2019 list in the field of Biotechnology and Organics. , According to statistics compiled ... total of 259 patents issued in technology center 1600 during 2019. Technology center 1600 ...
(Date:2/21/2020)... ... February 20, 2020 , ... The dietary supplement ... consumers that what’s listed on an ingredient panel is actually in their product. ... solution with the adoption of CertainT, which is designed to protect the intellectual ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... the life sciences industry, today announced the opening of a new office in ... Red Nucleus R&D. , Red Nucleus announced the new office in response to ...
Breaking Biology Technology:
Cached News: