Penn researchers find role for microRNAs in an...( P>It has become increasingly clear tha...)

P>"It has become increasingly clear that microRNAs are abnormally expressed in many types of cancer and select microRNAs have been demonstrated to act as a new type of oncogene," Mendell said. "As such, microRNAs represent an entirely new class of potential targets for cancer therapy." According to Mendell, an "anti-sense" version of miR-17-92 could bind to miR-17-92, thereby canceling its effects. If it is possible to deliver "regular" miR-17-92 to increase angiogenesis, as was demonstrated in the Nature Genetics paper, it may be possible to deliver anti-sense miR-17-92 to decrease angiogenesis and tumor growth.

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Contact: Greg Lester
glester@pobox.upenn.edu
215-573-6604
University of Pennsylvania
31-Jul-2006

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