HOME >> BIOLOGY >> NEWS
Penn scientists engineer small molecules to probe proteins deep inside cell membrane

PHILADELPHIA -- Proteins, which form much of the molecular machinery required for life, are the targets of most drug molecules. One third of all proteins are membrane proteins embedded within the cells fatty outer layer. While scientists can easily study the other two-thirds using such tools as antibodies, they have not had such methods to investigate the membrane-embedded portions of proteins.

To probe the secrets of these seemingly inaccessible proteins, researchers at the University of Pennsylvania School of Medicine have designed peptides that are able to bind to specific regions of transmembrane proteins, using computer algorithms, and information from existing protein sequence and structure databases. This study, which appears in the March 30 issue of Science, looks at how the binding of these designed peptides affects the crucial first steps in blood clotting.

"We can now actually interrogate parts of proteins within the membrane," says senior author William F. DeGrado, PhD, Professor of Biochemistry and Biophysics. "We used computer programs to design small proteins called peptides that can bind to only one of a number of closely related membrane proteins."

The researchers targeted two transmembrane proteins called integrins that influence the behavior of platelets, small blood cells important in clotting. One of these, the IIb3 integrin, the most prominent integrin on platelets, is involved in making platelet aggregates, an important first step in the clotting process.

The other integrin, called V3, behaves much like IIb3, in that it causes platelets to stick to certain proteins on the outside of the cell. "We wanted to see if we could differentiate between the two integrins using two different peptides and, in fact, we can," notes co-senior author Joel Bennett, MD, Professor of Medicine, who works with proteins and cells important in clotting.

When the designed peptide is inserted into the platelet
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
30-Mar-2007


Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Smithsonian scientists show differing patterns of rainforest biodiversity
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Cornell scientists link E. coli bacteria to Crohns disease
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. ASBMB taps 8 scientists and 1 politician for top awards
7. UF, French scientists seek test to detect gene doping in athletes
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. Forsyth scientists gain new understanding of adult stem cell regulation
10. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
11. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2020)... ... 2020 , ... Pebble Labs USA Inc. , a biotechnology company developing ... the mission of improving global food security, announced today that they have been selected ... Food- and Ag-Tech ' virtual event, a global initiative to drive innovation in feeding ...
(Date:4/26/2020)... Md. (PRWEB) , ... April 23, 2020 , ... ... sector, specializing in computer miniaturization, backed by FII Tech Growth managed by Fondo ... operating in the biomedical market, for the development of Respira, a new non-invasive ...
(Date:4/22/2020)... ... 21, 2020 , ... Captis Biotechnology, Inc. announced it has ... patent development support for early stage startups. The investment will support Captis’ mission ... and precancerous pancreatic lesions with simple, accurate and practical technology. , “We are ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 14, 2020 , ... This new service offers clients a way ... questions answered quickly as the need arises. Lachman’s OnCall SMEs have extensive knowledge of ... rates. , Lachman OnCall™ SMEs are available normal business hours Monday through Friday ...
(Date:5/14/2020)... ... 12, 2020 , ... DuPont Nutrition & Biosciences (N&B) has ... personal care ingredients in Russia and Belarus. Beginning May 1, Interdisp JCS will ... care. , The GENENCARE®OSMS product line contains a range of all-natural, ...
(Date:5/14/2020)... ... May 13, 2020 , ... In collaboration with ... Workflows in the Life Science Lab . The comprehensive information source was created ... purification and liquid handling to contamination control. , The content hub features the ...
(Date:5/9/2020)... ... , ... Worldwide Business with kathy ireland® will be LIVE ... 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime ... from Techolution and Bravado Pharmaceuticals . , As leaders in ...
Breaking Biology Technology:
Cached News: