HOME >> BIOLOGY >> NEWS
Penn study finds inhaled anesthetics accelerate the appearance of brain plaque in animals

PHILADELPHIA Researchers at the University of Pennsylvania's School of Medicine have discovered that common inhaled anesthetics increase the number of amyloid plaques in the brains of animals, which might accelerate the onset of neurodegenerative diseases like Alzheimer's. Roderic Eckenhoff, MD, Vice Chair of Research in the University of Pennsylvania's Department of Anesthesia and Critical Care, and his co-authors, report their findings in the March 7th online edition of Neurobiology of Aging.

Every year over 100 million people undergo surgery worldwide, most under general anesthesia with an inhaled drug. These drugs clearly affect cognitive ability at least in the short term, but the growing concern is that inhaled anesthetics may affect a person well beyond the perioperative period, even permanently. Several factors appear to play a role in this subtle loss of cognitive ability, most notably age.

A specific effect of these drugs on dementias like Alzheimer's disease, though suspected for many years, has only been recently supported by data. In 2003, Eckenhoff's group showed that the inhaled anesthetics enhance the aggregation and cytotoxicity of the amyloid beta peptide. Just last month, a study reported that these drugs also enhance the production of amyloid beta in isolated cells. But these protein and cell culture studies are a long way from showing that an effect occurs in vivo. This new study provides the first evidence that the predicted effect occurs in animals.

"This animal study data suggests that we have to at least consider the possibility that anesthetics accelerate certain neurodegenerative disorders," said Eckenhoff. "In the field of Alzheimer's research, most effort is focused on delaying, not curing the disease. A delay in the onset of Alzheimer's disease of only three to five years would be considered a success. Therefore, if commonly used drugs, like anesthetics, are accelerating this disorder, even by a few years, then a
'"/>

Contact: Rick Cushman
rick.cushman@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
9-Mar-2007


Page: 1 2

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Clones on task serve greater good, evolutionary study shows
3. Pollution causes 40 percent of deaths worldwide, study finds
4. A study by the MUHC and McGill University opens a new door to understanding cancer
5. New study suggests Concord grape juice may provide protection against breast cancer
6. Preclinical study links gene to brain aneurysm formation
7. In limiting life span, study finds booming bacteria innocent
8. Multicenter study nets new lung tumor-suppressor gene
9. MIT study: Maturity brings richer memories
10. Chickadee, nutchatch presence in conifers increases tree growth, says CU-Boulder study
11. Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/9/2018)... ... August 08, 2018 , ... Specialty Med ... helps physicians bring the latest regenerative therapies and treatment options to their patients, ... 2018 in White Plains, NY. , The 2-day clinical collaboration ...
(Date:8/7/2018)... ... August 06, 2018 , ... BioMedGPS announces the launch ... Inspired by its medical device customers, BioMedGPS teamed up with a usability expert ... changes, SmartTRAK 3.0 touts a cleaner look, easier navigation and improved functionality. ...
(Date:8/2/2018)... , ... August 02, 2018 , ... ... solutions to pharmaceutical and biotech companies, today announced that Mark Jara, principal of ... inspiring people in the life sciences industry. Individuals named to PharmaVOICE 100 are ...
Breaking Biology News(10 mins):
(Date:8/14/2018)... ... August 14, 2018 , ... The growing interest in ... the Chinese Association of Orthopaedic Surgeons (CAOS) held in partnership with the North ... , Beijing, and Invibio Biomaterial Solutions partnered to demonstrate the new ...
(Date:8/9/2018)... ... August 08, 2018 , ... InTouchMD , the leading provider ... they will be exhibiting at Biotech Week Boston , September 4th – 7th ... Pulse platform, healthcare’s most powerful all in one marketing solution. Pulse is ...
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson Gumpertz ... (AEC) experts with building owners and managers for a full-day discussion on health ... symposium comes to Boston for the first time on Thursday, 13 September 2018, ...
(Date:7/31/2018)... ... July 31, 2018 , ... Leading ... covers methods for extracting and using adipose tissue-derived stem cells to treat or ... While this patent covers Canada specifically, VetStem has been issued similar patents ...
Breaking Biology Technology:
Cached News: