HOME >> BIOLOGY >> NEWS
Pepper component hot enough to trigger suicide in prostate cancer cells

Capsaicin, the stuff that turns up the heat in jalapeos, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, according to studies published in the March 15 issue of Cancer Research.

According to a team of researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, in collaboration with colleagues from UCLA, the pepper component caused human prostate cancer cells to undergo programmed cell death or apoptosis.

Capsaicin induced approximately 80 percent of prostate cancer cells growing in mice to follow the molecular pathways leading to apoptosis. Prostate cancer tumors treated with capsaicin were about one-fifth the size of tumors in non-treated mice.

"Capsaicin had a profound anti-proliferative effect on human prostate cancer cells in culture," said Sren Lehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Center and the UCLA School of Medicine. "It also dramatically slowed the development of prostate tumors formed by those human cell lines grown in mouse models."

Lehmann estimated that the dose of pepper extract fed orally to the mice was equivalent to giving 400 milligrams of capsaicin three times a week to a 200 pound man, roughly equivalent to between three and eight fresh habaera peppers depending on the pepper's capsaicin content. Habaeras are the highest rated pepper for capsaicin content according to the Scoville heat index. Habaero peppers, which are native to the Yucatan, typically contain up to 300,000 Scoville units. The more popular Jalapeo variety from Oaxaca, Mexico, and the southwest United States, contains 2,500 to 5,000 Scoville units.

As described in their study, the scientists observed that capsaicin inhibited the activity of NF-kappa Beta, a molecular mechanism that participates in the pathways leading to apoptosis in many cell types.

Apoptosis is a normal cellular event in many tissues that maintains a
'"/>

Contact: Russell Vanderboom, Ph.D.
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
15-Mar-2006


Page: 1 2 3

Related biology news :

1. Marijuana component opens the door for virus that causes Kaposis sarcoma
2. Research shows NPD1 protects a key component of vision
3. Light-activated therapy targets DNA components
4. UN, industry, others partner to create world standards for e-scrap recycling, harvesting components
5. Researchers in Montral and the US create model of key immune-system component
6. Scientists discover two-component lantibiotic with therapeutic potential
7. The power behind insect flight: Researchers reveal key kinetic component
8. African parasite makes component of fat differently from all other organisms
9. Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
10. Mice lacking key immune component still control chronic viral infections
11. New study reveals components of cocoa may enhance the appearance of the skin

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/27/2019)... Fla. (PRWEB) , ... October 26, 2019 , ... Since ... their unique reseller program. By prioritizing the success of their clients, they’ve earned a ... years in a row, and they’ve won many additional awards and accolades along the ...
(Date:10/26/2019)... , ... October 24, 2019 ... ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, gene ... during the “Manufacturing and Bioprocessing Track” at the forthcoming American Association of ...
(Date:10/22/2019)... (PRWEB) , ... October 21, 2019 , ... Join ... MS, Director of Bioanalytical in a live session on Thursday, October 31, ... CRO partner. , A good CRO partner should have expertise in method development, ...
Breaking Biology News(10 mins):
(Date:10/22/2019)... (PRWEB) , ... October 22, 2019 , ... Catalent, a ... Supply Services and Drug Product Technologies Integration, will participate in a panel session titled ... (HPCLC), to be held at the Gwen Hotel, Chicago, on Oct. 28-30, 2019. , ...
(Date:10/22/2019)... ... , ... DermBiont, a clinical stage microbiome biotechnology company developing ... safety endpoints, with no application site reactions and no adverse events, in a ... tinea pedis (athlete’s foot). Additionally, the trial demonstrated a clinical response with improvement ...
(Date:10/17/2019)... ... October 16, 2019 , ... My ... counseling information, has published a new white paper that explores how frequently medical ... as to how patients and medical providers can be kept informed as changes ...
(Date:10/10/2019)... ... October 09, 2019 , ... The International ... Commissioner, FDA, as a newly-confirmed keynote speaker for the 2019 ISPE Annual ... USA. , Dr. Abernethy, a hematologist/oncologist and palliative medicine physician, is an internationally ...
Breaking Biology Technology:
Cached News: