HOME >> BIOLOGY >> NEWS
Pepper component hot enough to trigger suicide in prostate cancer cells

Capsaicin, the stuff that turns up the heat in jalapeos, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, according to studies published in the March 15 issue of Cancer Research.

According to a team of researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, in collaboration with colleagues from UCLA, the pepper component caused human prostate cancer cells to undergo programmed cell death or apoptosis.

Capsaicin induced approximately 80 percent of prostate cancer cells growing in mice to follow the molecular pathways leading to apoptosis. Prostate cancer tumors treated with capsaicin were about one-fifth the size of tumors in non-treated mice.

"Capsaicin had a profound anti-proliferative effect on human prostate cancer cells in culture," said Sren Lehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Center and the UCLA School of Medicine. "It also dramatically slowed the development of prostate tumors formed by those human cell lines grown in mouse models."

Lehmann estimated that the dose of pepper extract fed orally to the mice was equivalent to giving 400 milligrams of capsaicin three times a week to a 200 pound man, roughly equivalent to between three and eight fresh habaera peppers depending on the pepper's capsaicin content. Habaeras are the highest rated pepper for capsaicin content according to the Scoville heat index. Habaero peppers, which are native to the Yucatan, typically contain up to 300,000 Scoville units. The more popular Jalapeo variety from Oaxaca, Mexico, and the southwest United States, contains 2,500 to 5,000 Scoville units.

As described in their study, the scientists observed that capsaicin inhibited the activity of NF-kappa Beta, a molecular mechanism that participates in the pathways leading to apoptosis in many cell types.

Apoptosis is a normal cellular event in many tissues that maintains a
'"/>

Contact: Russell Vanderboom, Ph.D.
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
15-Mar-2006


Page: 1 2 3

Related biology news :

1. Marijuana component opens the door for virus that causes Kaposis sarcoma
2. Research shows NPD1 protects a key component of vision
3. Light-activated therapy targets DNA components
4. UN, industry, others partner to create world standards for e-scrap recycling, harvesting components
5. Researchers in Montral and the US create model of key immune-system component
6. Scientists discover two-component lantibiotic with therapeutic potential
7. The power behind insect flight: Researchers reveal key kinetic component
8. African parasite makes component of fat differently from all other organisms
9. Insulin pathway component explains insulin resistance, age-associated metabolic syndrome
10. Mice lacking key immune component still control chronic viral infections
11. New study reveals components of cocoa may enhance the appearance of the skin

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... 2020 , ... Modality Solutions, a biopharmaceutical cold chain validation engineering ... The list is the most prestigious ranking of the nation’s fastest-growing private companies. Modality ... list, reported three-year revenue growth of 71 percent. , The Inc. 5000 list ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... expo uniting life science, data science, informatics and IT leaders goes VIRTUAL and ... period of uncertainty and change, Bio-IT takes the leadership role of keeping our ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... is pleased to announce that Eric Chen and Jessica Wong have joined the ... Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
Breaking Biology Technology:
Cached News: