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Peramivir protects mice from lethal H5N1 infection

as a preventive measure during an outbreak to decrease the risk of infection," he said. Boltz is first author of a paper, which was presented April 30 at the 20th International Conference on Antiviral Research in Palm Springs, Calif.

"We were surprised to see a 40 percent survival rate among mice after just a single dose of peramivir," said Elena A. Govorkova, Ph.D., a scientific manager in the Infectious Diseases department at St. Jude. Govorkova is the papers senior author.

"Our findings support the use of peramivir during a pandemic, and we are currently studying the emergence of H5N1 variants that are resistant to this drug and may occur in the course of treatment," said Natalia A. Ilyushina, Ph.D., a postdoctoral fellow in Websters laboratory. Ilyushina is a co-author of the paper.


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Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
1-May-2007


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