Pezcoller Foundation-AACR International Award for Cancer Research recognizes Mina ...( ser understanding of how cells function...)

ser understanding of how cells function in three-dimensional living tissue as opposed to the two-dimensional culture dish. Her group continues to do pioneering work in this area, and in a recent article in Science her group described a new assay using micropatterns of cells sandwiched between two layers of ECM gels, and showed how mammary cells regulate branching which could be used to understand how breast cancer cells become invasive.

The citation for the Pezcoller Foundation-AACR award points out how for over three decades, Bissells elegant studies have revealed that the critical unit of biological function is the integrated signaling circuit provided by the tissue (organ) architecture. She is being honored for systematically looking beyond the single cell, showing that the interaction of cells with each other and with the ECM and the rest of the microenvironment influence cell proliferation, survival, morphogenesis, differentiation, and cell fate, all processes that go awry in cancer. These studies are innovative and the approaches imaginative, combined with rigor and persistence. The concepts she has developed are fundamental to normal tissue morphogenesis and cancer, and the impact of her work is profound for how we view biological regulation. In short, Bissell has taken an original and refreshing approach that has produced revolutionary new concepts.

Bissell received her Bachelors degree in chemistry with honors from Radcliffe/Harvard College. She received her Ph.D. in microbiology/molecular genetics from Harvard University. She began her career as a Milton Fellow at Harvard University in 1969, subsequently serving as an American Cancer Society Fellow at UCB. In 1972 she joined the Staff of Lawrence Berkeley National Laboratory becoming a Senior Scientist in 1976. She served as the Director of the Cell and Molecular Biology Division from 1988-1992; as the Director of all Life Sciences from 1992-2002; as the Associate Director of B
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Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
27-Mar-2007

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