HOME >> BIOLOGY >> NEWS
Phoenix rising: Scientists resuscitate a 5 million-year-old retrovirus

VILLEJUIF, France (Tues., Oct. 31, 2006) -- A team of scientists has reconstructed the DNA sequence of a 5-million-year-old retrovirus and shown that it is able to produce infectious particles. The retrovirus--named Phoenix--is the ancestor of a large family of mobile DNA elements, some of which may play a role in cancer. The study, which is the first to generate an infectious retrovirus from a mobile element in the human genome, is considered a breakthrough for the field of retrovirus research. The findings are reported in Genome Research.

"Phoenix became frozen in time after it integrated into the human genome about 5 million years ago," explains Dr. Thierry Heidmann, lead investigator on the project. "In our study, we've recovered this ancestral state and shown that it has the potential for infectivity."

Retroviruses, whose genomes consist of RNA, can create DNA "copies" of the RNA genomes and incorporate them into the genomes of their hosts. Phoenix belongs to a sub-category of retroviruses--known as HERVs (human endogenous retroviruses)--which inserted copies into the human germline millions of years ago. These copies were subsequently passed on from generation to generation. Remnants of HERVs now comprise nearly 8% of the human genome, but most were rendered inactive long ago by mutations.

Heidmann and his colleagues set out to re-activate one family of HERVs, called the HERV-K(HML2) family, an evolutionarily "young" family of retroviral elements. They aligned HERV-K(HML2) elements, determined their consensus sequence, and then constructed a retrovirus--Phoenix--from the consensus sequence by mutating existing HERV-K(HML2) copies.

In addition, the researchers showed that Phoenix could form particles capable of infecting mammalian cells in culture. Infectivity was very low, presumably because host cells have evolved mechanisms to resist uncontrolled virus propagation, as has been repeatedly ob
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
30-Oct-2006


Page: 1 2

Related biology news :

1. 20th annual convention of US naturopathic physicians convenes Aug. 24, 2005 in Phoenix
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
4. Scientists move closer to bio-engineered bladders
5. Scientists find stem cell switch
6. Scientists discover new way to study nanostructures
7. Scientists a step closer to understanding how anaesthetics work in the brain
8. Scientists to make news at Computational Biology Conference
9. Accident-prone? Scientists link brain function to knee injuries
10. Scientists take next step in understanding potential target for ovarian cancer treatment
11. Scientists find brown fat master switch

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... Minn. , Jan. 18, 2017 ... technology company that supports the entire spectrum of ... has been another record-breaking year for the organization ... market interest in MedNet,s eClinical products and services. ... the tremendous marketplace success of iMedNet ...
(Date:1/12/2017)... 2017  Trovagene, Inc. (NASDAQ: TROV ), ... announced that it has signed agreements with seven strategic ... Middle East for commercialization of ... first wave of international distribution agreements for Trovagene,s CLIA ... The initial partners will introduce Trovagene,s liquid ...
(Date:1/12/2017)... and PUNE, India , January 12, 2017 ... Opportunities and Forecasts, 2015 - 2022," projects that the global biometric technology market is ... 19.4% from 2016 to 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 23, 2017 , ... Oklahoma City based Sigma Blood Systems has established ... PERFEQTA software and legacy product QC Manager 2.0. , Sigma Blood Systems CEO, ... and thrilled that they have decided to implement PERFEQTA and QC Manager 2.0, with ...
(Date:1/24/2017)... , January 23, 2017 According ... Market by Type (Genetic, Cell-based (CD34, PBMC, BLT)), Application ... User (Pharmaceutical & Biotech Companies, CRO) - Global Forecast ... global Humanized Mouse Model Market for the forecast period ... reach USD 116.0 Million by 2021 from USD 73.3 ...
(Date:1/24/2017)... Jan. 23, 2017  Today, the Fisher Center for ... funded an important study that could lead to the ... of Alzheimer,s disease. This groundbreaking research was conducted by ... by Nobel Laureate Dr. Paul Greengard , in ... Fisher Center scientists have linked a mutation ...
(Date:1/23/2017)... Fl (PRWEB) , ... January 23, 2017 , ... ... venture-backed teleradiology and telemedicine company announces significant growth last year adding 65 new ... Veterans Authority and US Army medical centers as well as one of US ...
Breaking Biology Technology:
Cached News: