Einerhand says that in a study, polyunsaturated fatty acids (PUFAs) derived from "Korean pine nuts, which have been part of our diet since before ancient Greek and Roman times, stimulated two well-known appetite suppressing peptide hormones at the same time that overweight women reported significantly less desire to eat only 30 minutes after ingestion," compared with an olive oil placebo.
In a paper being presented in an American Physiological Society session at Experimental Biology 2006, Einerhand reports that "in this randomized, double-blind cross-over trial, the greatest effect was observed after just 30 minutes, with the 18 women reporting a 29% reduction in "desire to eat" and a 36% drop in "prospective food intake" scores. Their subjective feelings of appetite were evaluated by visual analog scales, a validated scoring system.
The experiment found a parallel and significant increase in cholecystokinin (CCK) of 60% and glucagon-like peptide 1 (GLP1) of 25% that remained as long as four hours after ingestion. CCK and GLP1 are appetite suppressors, which "send signals of satiation to the brain diminishing the desire to eat and food intake usually significantly," she adds.
The experiment utilized 3 grams of a product called PinnoThin, comprised of over 88% Korean pine nut PUFAs, and which is marketed by Lipid Nutrition, a division of Loders Croklaan, of the Netherlands.
*Paper presentation: "Korean pine nut fatty acids affect appetite sensations, plasma CCK and GLP1 in overweight subjects," 12:30 p.m.-3 p.m. Monday April 3, Physiology Obesity and Satiety 494.2/board #C781. On view 7:30 a.m. - 4 p.m. Research was b
Contact: Mayer Resnick
American Physiological Society