HOME >> BIOLOGY >> NEWS
Pituitary hormone implicated in bone loss after menopause

the fine balance between bone formation and resorption. After menopause, resorption exceeds new bone formation, leading to a net bone loss that can be slowed by estrogen therapy through mechanisms that have remained somewhat murky, Zaidi said.

However, emerging evidence has begun to cast some doubt on whether estrogen deficiency can fully explain bone loss after menopause, he added. For example, mice without an intact pituitary gland become resistant to the effects of ovary loss on bone density. FSH levels also show a closer correlation than estrogen levels to the rate of bone turnover in postmenopausal women.

The researchers now show that mice lacking FSH or its receptor become resistant to bone loss despite severe loss of ovarian function. In mice with normal ovaries and approximately half the normal concentration of FSH, bone mass increased due to a decline in bone resorption by cells known as osteoclasts, which break down bone. Indeed, they report, FSH stimulates receptors found on the surface of bone-degrading osteoclasts and their precursors, leading to the bone cells' formation and function.

The study suggests that FSH plays a role in the normal process by which bone is mobilized by osteoclasts before it can be replaced, Zaidi said.

"As you run or walk throughout life, microcracks develop in bone," he explained. "Therefore, bone remodeling and replacement with new bone is required to maintain skeletal integrity. Osteoclasts essentially dig around those cracks to clear the way for repairs."

In combination with the research group's earlier finding that thyroid-stimulating hormone directly regulates the skeleton, the findings revise the understanding of how pituitary-derived hormones function, Zaidi added. Scientist had thought pituitary hormones acted primarily through their effects on other endocrine glands.

"This should change the textbook picture of pituitary hormone physiology," he said.


'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
20-Apr-2006


Page: 1 2

Related biology news :

1. Circadian clock controls plant growth hormone
2. Role of thyroid hormones in slumber under investigation at Rutgers
3. Breast cancer and hormone therapy -- A looking-glass mirror?
4. IMS updated recommendations on postmenopausal hormone therapy
5. Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
6. Steroid hormones regulate the body clock
7. Scientists find hormone activity explains adolescent mood swings
8. Pregnancy hormone increases nerve cells insulation, restores damage
9. Pregnancy hormone key to repairing nerve cell damage
10. Male sweat boosts womens hormone levels
11. Joslin-led study uncovers role of appetite hormone MCH in insulin production

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pituitary hormone implicated bone loss after menopause

(Date:4/15/2014)... The Royal Netherlands Academy of Arts and Sciences (KNAW) ... who have been awarded prestigious Heineken Prizes (one million ... the Heineken Prizes for their great merits to science. ... first Heineken Prize, awarded to the Austrian-American chemist Erwin ... this year,s Heineken Prizes to the following laureates: ...
(Date:4/15/2014)... that the genetic code is far more complex ... building blocks adenine, cytosine, guanine, and thymine, numerous ... assume that the newly discovered nucleic acid modifications ... extends and complements the genetic code. "The new ... standard alphabet," explained Professor Mark Helm of the ...
(Date:4/15/2014)... April 15, 2014 New research, partially funded by ... Federation, shows that consumers can improve their diets simply ... their daily meals. , In a ... and Nutrition Sciences , lead author Theresa Nicklas, DrPH, ... and Nutrition Examination Survey datasets from 2005-2010 and evaluated ...
Breaking Biology News(10 mins):Five scientists awarded prestigious Heineken Prizes 2German Research Foundation approves new priority program in the life sciences 2Eating rice boosts diet quality, reduces body weight and improves markers for health 2Eating rice boosts diet quality, reduces body weight and improves markers for health 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
Cached News: