HOME >> BIOLOGY >> NEWS
Plague proteome reveals proteins linked to infection

RICHLAND, Wash. -- Recreating growth conditions in flea carriers and mammal hosts, Pacific Northwest National Laboratory scientists have uncovered 176 proteins and likely proteins in the plague-bacterium Yersinia pestis whose numbers rise and fall according to the diseases virulence.

The team, led by the Department of Energy laboratory staff scientists Mary Lipton and Kim Hixson, identified the proteins as unique biomarkers related specifically to growth condition, according to a study in the latest issue of the Journal of Proteome Research. Biomarkers associated with disease progression show promise as detection tools in public health and biodefense and can guide drug and vaccine designers in their quest to disrupt the microbes ability to infect.

Y. pestis is the bacterium that caused the infamous Black Death plagues. Fleas are vectors for the disease and can spread it to rodent and human hosts. This study mimicked environmental conditions of Y. pestis in flea and in mammalian systems.

The proteome is a survey of proteins in a cell. Lipton, Hixson and colleagues at the PNNL-based Environmental Molecular Sciences Laboratory and Lawrence Livermore National Laboratory used proteomic techniques called accurate mass and time tag mass spectrometry and clustering analysis to compare abundance changes in 992 proteins under four different growth conditions, at 26 degrees and 37 degrees Celsius and with and without calcium.

They found 89 candidate proteins with similar abundance changes to 29 known virulence-linked proteins, and an additional 87 disease-condition-associated hypothetical proteins. The Institute for Genomic Research defines a hypothetical protein as one identified by a gene-finding algorithm that matches no other known protein sequence or contains no other evidence that it is an actual product of a gene.

The study authors said the same approach is being applied to a search for biomarkers across a wide r
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
22-Nov-2006


Page: 1 2

Related biology news :

1. A wolf in sheeps clothing: Plague bacteria reveal one of their virulence tricks
2. Plague agent helps UT Southwestern researchers find novel signaling system in cells
3. Protein structures for the entire yeast proteome
4. MicroRNAs, alternative splicing and the muscle proteome
5. Sperm proteome gives tantalizing glimpse towards the origin of sex
6. Scientists characterize proteome of human cornea
7. Satellite tracking reveals threats to Borneo pygmy elephants
8. New technology reveals seal behavior
9. Innovative research technique reveals another natural wonder in Yellowstone Park
10. Mathematics reveals genetic pattern of tumor growth
11. CU study reveals why starling females cheat

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 18, 2019 , ... ... Meredith James, HT, PMP, to its executive team as Vice President of Operations. ... drug development. In her new role, Ms. James is responsible for ensuring on-time ...
(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
(Date:7/17/2019)... ... ... Imagine using a simple, portable test to detect cancer before malignant tissues ... South Dakota School of Mines & Technology researcher Congzhou Wang, Ph.D., these ideas are ... to monitor and prevent disease,” says Wang. , Wang, an assistant professor in ...
Breaking Biology News(10 mins):
(Date:7/26/2019)... ... July 25, 2019 , ... LeadingBiotech , an exclusive ... announces its Boston BD conference to be held on September 10, ... Boston , the event provides an opportunity for attendees to leverage insight from ...
(Date:7/17/2019)... , ... July 16, 2019 ... ... long-term strategic agreement for the development and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), ... this collaboration, AveXis, a Novartis company, will have dedicated manufacturing space at ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, ... Where Beasts Meet Biotech. The film focuses on regenerative veterinary medicine as a ... Pharm was recently included in the Brentwood and Pacific Palisades International Film ...
(Date:6/11/2019)... ... June 10, 2019 , ... Thought Technology Ltd is ... of Biofeedback Tech Ltd as its authorised distributor for the UK ... many therapeutic treatments and clinical assessment protocols to treat stress related disorders as ...
Breaking Biology Technology:
Cached News: