Plant-derived molecules, genetic manipulation point to future chemoprevention methods

BOSTON -- Scientists are using genetic studies and natural chemicals, such as plant-derived triterpenoids, to further our knowledge on how genetic and early molecular interactions can lead to cancer, and how those early interactions can be manipulated to stave off a variety of cancers. The latest studies with new and promising chemopreventive agents were presented at the American Association for Cancer Research's Frontiers in Cancer Prevention Research meeting today.

Trterpenoids and the rexinoid LG100268 prevent lung tumors induced by vinyl carbamate in strain A/J mice

New synthetic drugs called triterpenoids which owe their origins to plant molecules have demonstrated their effectiveness in slowing the growth of lung cancer tumors, a research team from Dartmouth University has found.

Following up on previous work showing strong links between inflammation and the development of cancer, Karen Liby, Ph.D., a postdoctoral fellow, and her colleagues found that the triterpenoid CDDO-MA, currently undergoing trails for leukemia and solid tumors (sponsored by Reata Pharmaceuticals), significantly reduced the number and sizes of tumors in mice. In addition, a chemically related drug developed by Ligand Pharmaceuticals called LG100268 was effective at preventing tumor growth.

"Lung cancer is the leading cause of cancer deaths in the United States," said Liby. "Since the mortality from this disease is significant, and prognoses are poor once a patient has been diagnosed, prevention may provide the only avenues to combat this particular cancer. We think this study shows a promising role for triterpenoids and the drug LG100268 in stopping lung tumor growth."

The scientists knew that the compounds had anti-inflammatory properties and that LG100268 in particular could stop certain types of breast cancer in animal models. The compounds inhibited inflammation in a number of ways: halting nitric oxide production, blocking cyclo

Contact: Warren Froelich
American Association for Cancer Research

Page: 1 2 3 4 5

Related biology news :

1. Plant-derived vaccines safeguard against deadly plague
2. New nanotechnology able to examine single molecules, aiding in determining gene expression
3. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
4. Does the desire to consume alcohol and tobacco come from our genetic makeup?
5. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
6. Penn researchers discover pathway that eliminates genetic defects in red blood cells
7. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
8. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
9. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
10. Identified main genetic variants involved in response to HIV
11. Restless legs genetics on the move

Post Your Comments:

(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
Breaking Biology Technology:
Cached News: