Plexxikon advances first oncology development candidate

Plexxikon Inc. today announced that the company has initiated IND-enabling studies with PLX4032, the company's oncogenic B-Raf inhibitor, a novel, small molecule drug candidate for the treatment of cancer. This compound selectively inhibits the cancer causing form of the B-Raf gene, a mutation found in 70% of skin cancers and a significant number of colorectal, ovarian and thyroid cancers. At the 97th Annual Meeting of the American Association for Cancer Research, Plexxikon scientists presented preclinical data demonstrating that a low dose of this oral V600E B-Raf inhibitor preferentially stopped tumor growth in malignant melanoma and colorectal cancer cells.

In the oral presentation titled "Development of a Novel Inhibitor of Oncogenic B-Raf," (Abstract #2412), Plexxikon scientists report that the company's V600E B-Raf inhibitor showed strong selectivity and potency against specific melanoma and colorectal cell lines. In addition, this compound demonstrated robust efficacy in xenograft models using a once-daily low oral dose, with evidence of tumor shrinkage and prolonged delay of tumor growth for a significant post-dosing period.

"Plexxikon's V600E B-Raf inhibitor may represent the first opportunity to target a disease-specific gene found only in cancerous cells and not in normal cells. With its clean selectivity profile, and specific targeting of tumors, we anticipate this drug candidate will be very safe for patients," said K. Peter Hirth, Ph.D., chief executive officer of Plexxikon Inc. "Plexxikon's advancement of this oncology candidate to development, together with our broad program in diabetes and metabolic disease, further demonstrate the depth and breadth of our novel drug discovery platform. We intend to file an IND (Investigational New Drug) application and initiate Phase 1 clinical trials in the second half of 2006 for our oncogenic B-Raf inhibitor."

Plexxikon's Oncology Programs Driven by Advent of Personalized Medici

Contact: Angela Bitting
AB Corporate Communications

Page: 1 2

Related biology news :

1. Study advances vCJD prion detection
2. New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
3. SNM advances professional definition for molecular imaging
4. New research advances energy efficiency, safety and performance of public transit
5. InfoSNM highlights advances in computer, information sciences for molecular imaging
6. Mouse model advances understanding of synovial sarcoma
7. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
8. Study advances evidence for receptors role in alcohol pleasure and problems
9. MIT bioengineer advances survival, promise of adult stem cells
10. AAAS Oceans Panel examines advances in science and technology to boost fishery sustainability
11. Research advances on nanotech workplace health and safety

Post Your Comments:

(Date:1/20/2019)... (PRWEB) , ... January 16, 2019 , ... January has ... cooking events company. Not only has the company already hosted several of its ... Fortune 500 companies, Amazon and Janssen Pharmaceuticals, later this month. , Since 2008, ...
(Date:1/20/2019)... (PRWEB) , ... January 18, 2019 , ... Boston-based Laboratory ... SmartLabs in an effort to better express its continued expansion and service offerings ... calls for a new kind of lab: one that is more agile and adaptable ...
(Date:1/14/2019)... , ... January 14, 2019 , ... ... at 11am EST (4pm GMT) to hear about key topics in data quality, ...     Computer-administered ratings ,     Patient engagement ,     Smartphone and wearable based ...
Breaking Biology News(10 mins):
(Date:2/14/2019)... ... February 14, 2019 , ... Leak Detection Associates ... the pharmaceutical, biotechnology and food industries, formally announced today the appointment of two ... has been named Chief Executive Officer and will oversee all aspects of the ...
(Date:2/2/2019)... ... 2019 , ... Dust off your Doc Martens, Virun Nutra-BioSciences is fusing punk ... West Music and Tech Festival at the ESports Arena in Santa Ana on Wednesday ... beverages, and dietary supplement industries, the Nuriv Music and Tech Festival is scheduled one ...
(Date:1/30/2019)... (PRWEB) , ... January 29, 2019 , ... ... Contract Development and Manufacturing Organization (CDMO) serving the global biopharmaceutical and biotechnology industries ... funding of $59.1 million backed by multiple global investors lead by China's State ...
(Date:1/30/2019)... ... January 29, 2019 , ... Could ... over something like a tricky math problem on an online tutoring program? Could ... Polytechnic Institute (WPI) computer science assistant professor Erin Solovey is working ...
Breaking Biology Technology:
Cached News: