HOME >> BIOLOGY >> NEWS
Plexxikon advances first oncology development candidate

Plexxikon Inc. today announced that the company has initiated IND-enabling studies with PLX4032, the company's oncogenic B-Raf inhibitor, a novel, small molecule drug candidate for the treatment of cancer. This compound selectively inhibits the cancer causing form of the B-Raf gene, a mutation found in 70% of skin cancers and a significant number of colorectal, ovarian and thyroid cancers. At the 97th Annual Meeting of the American Association for Cancer Research, Plexxikon scientists presented preclinical data demonstrating that a low dose of this oral V600E B-Raf inhibitor preferentially stopped tumor growth in malignant melanoma and colorectal cancer cells.

In the oral presentation titled "Development of a Novel Inhibitor of Oncogenic B-Raf," (Abstract #2412), Plexxikon scientists report that the company's V600E B-Raf inhibitor showed strong selectivity and potency against specific melanoma and colorectal cell lines. In addition, this compound demonstrated robust efficacy in xenograft models using a once-daily low oral dose, with evidence of tumor shrinkage and prolonged delay of tumor growth for a significant post-dosing period.

"Plexxikon's V600E B-Raf inhibitor may represent the first opportunity to target a disease-specific gene found only in cancerous cells and not in normal cells. With its clean selectivity profile, and specific targeting of tumors, we anticipate this drug candidate will be very safe for patients," said K. Peter Hirth, Ph.D., chief executive officer of Plexxikon Inc. "Plexxikon's advancement of this oncology candidate to development, together with our broad program in diabetes and metabolic disease, further demonstrate the depth and breadth of our novel drug discovery platform. We intend to file an IND (Investigational New Drug) application and initiate Phase 1 clinical trials in the second half of 2006 for our oncogenic B-Raf inhibitor."

Plexxikon's Oncology Programs Driven by Advent of Personalized Medici
'"/>

Contact: Angela Bitting
a.bitting@comcast.net
925-202-6211
AB Corporate Communications
3-Apr-2006


Page: 1 2

Related biology news :

1. Study advances vCJD prion detection
2. New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
3. SNM advances professional definition for molecular imaging
4. New research advances energy efficiency, safety and performance of public transit
5. InfoSNM highlights advances in computer, information sciences for molecular imaging
6. Mouse model advances understanding of synovial sarcoma
7. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
8. Study advances evidence for receptors role in alcohol pleasure and problems
9. MIT bioengineer advances survival, promise of adult stem cells
10. AAAS Oceans Panel examines advances in science and technology to boost fishery sustainability
11. Research advances on nanotech workplace health and safety

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/20/2018)... Calif. (PRWEB) , ... November 19, 2018 , ... ... Emsculpt in the Bay Area -- the first and only non-invasive buttock ... contractions, Emsculpt is FDA cleared to strengthen, tone and firm the buttocks to ...
(Date:11/16/2018)... ... November 16, 2018 , ... ... was awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby Advocacy Award at ... Advocacy Award, named “The Selby” after longtime IBWA contributor Shayron Barnes-Selby, is awarded ...
(Date:11/15/2018)... ... November 14, 2018 , ... Researchers at ... speeds up the analysis and publication of biomedical data from many months or ... Until now, the primary method available to share biomedical research data has been ...
Breaking Biology News(10 mins):
(Date:11/29/2018)... ... 2018 , ... RAGS, today announced the closing of a $1.5 million Second ... existing investor and board member Jeremy Andrus, CEO of Traeger Grills, as well as ... enable the company to accelerate its growth and expand the product line. RAGS has ...
(Date:11/20/2018)... ... 2018 , ... Patients with missing teeth in Sandy Springs, GA, Alpharetta, GA, ... Myers at THE DENTIST Centers without a referral. Dr. Myers is a skilled cosmetic ... years. He now offers skilled dental care in two practice locations THE DENTIST Windward ...
(Date:11/13/2018)... ... 2018 , ... AseptiScope(TM), Inc. announces it is advancing its ... last week, confirm pose a significant health risk. The two large clinical ... are often improperly or rarely disinfected. In the AJIC November 6 issue, investigators ...
(Date:11/11/2018)... SAN DIEGO (PRWEB) , ... November 09, 2018 , ... ... named a CES® 2019 Innovation Awards Honoree for DFree ®, the ... and notifies you when it’s time to go to the bathroom. The announcement was ...
Breaking Biology Technology:
Cached News: