HOME >> BIOLOGY >> NEWS
Polymer gel can block toxic leakage problem in gene therapy

DURHAM, N.C. -- Duke University biomedical engineers have devised a potentially patentable method to arrest toxic leakages of genetically engineered viruses that have plagued attempts to use gene therapy against cancerous tumors. The problem has been that viruses carrying anti-tumor genes have tended to leak from tumors, proving toxic to other body tissues.

The researchers have developed a biocompatible polymer that briefly changes from a liquid at 39 degrees Fahrenheit to a gel at body temperatures to block most gene-bearing viruses from being diverted through the blood stream to the wrong targets, the scientists reported in research journals.

"With this method we can reduce the misdirected virus dissemination by a factor of 100 to 1,000 times," said Fan Yuan, an associate biomedical engineering professor at Duke's Pratt School of Engineering who led the studies. "That's enough of a reduction to solve the problem."

The work was supported by the National Science Foundation.

According to Yuan, about 66 percent of the 918 gene therapy clinical trials conducted in 24 countries between 1989 and 2004 were aimed at treating cancer.

His interdisciplinary group from the Pratt School and the Duke Medical Center's radiation oncology department studied a preferred kind of anti-cancer gene therapy that uses relatively harmless adenoviruses to infect tumor cells. Once in a targeted tumor, genes in these genetically modified viruses are designed to express their modified genes to manufacture proteins that can either trigger tumor cell death or stimulate the immune system to attack the cancer.

Yuan said he and other Duke researchers have found that, because of the small size of pores in blood vessel walls and other access points, these adenoviruses cannot reach the majority of tumor cells by being injected into the blood stream but instead must be injected directly into tumors themselves.

However, direct intratumoral injectio
'"/>

Contact: Monte Basgall
monte.basgall@duke.edu
919-681-8057
Duke University
18-Nov-2005


Page: 1 2 3 4

Related biology news :

1. Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications
2. Polymer aids in blood clotting, pointing way to new treatment
3. Polymer expert writes text about better, inexpensive ways to create plastic
4. Polymers with copper show promise for implanted sensors
5. Molecule blocks gene, sheds light on liver cancer
6. Negative effects of plastics additive blocked by nutrient supplements
7. MIT researchers probe bones tiny building blocks
8. Blood sugars manufacture limited by building blocks supply
9. Removing a hydrogen fuel-cell roadblock
10. New compound prevents alcoholic behavior, relapse in animals by blocking stress response
11. Drug blocks lethal motor-neuron disease in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... , March 15, 2016 ... report published by Transparency Market Research "Digital Door Lock Systems ... Forecast 2015 - 2023," the global digital door lock systems ... Mn in 2014 and is forecast to grow at a ... of micro, small and medium enterprises (MSMEs) across the world ...
(Date:3/11/2016)... -- --> --> ... Market by Technology (Pattern Recognition), by Component (Hardware, Software, ... (On-Premises and Cloud), by Industry Vertical and by Region ... global market is expected to grow from USD 12.49 ... at a CAGR of 19.1%. , ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... May 4, 2016 According to ... "Metabolomics Market - Global Industry Analysis, Size, Share, Growth, ... is anticipated to expand at a CAGR of 17.1% ... by 2024. Metabolomics is the extensive study ... biofluids, tissues or organisms. Together, these small molecules and ...
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published by the Boston Business ... fastest-growing private companies; a small percentage of the state's 615,000+ small businesses. The list ... change in revenue from 2012 to 2015. , As this award comes ...
(Date:5/3/2016)... , May 3, 2016 ... Assessing Developers and Producers of Those Competitor Biologics  ... to Companies, Activities and Prospects ,  Who ... companies? And what are their sales potentials? Discover, ... you see results, trends, opportunities and revenue forecasting. ...
(Date:5/2/2016)... ... May 02, 2016 , ... Meister Media Worldwide launches ... look and added functionality give the agricultural world a taste of Meister Media ... in agriculture – from precision farming via satellites and Unmanned Aerial Vehicles (UAVs) ...
Breaking Biology Technology:
Cached News: