HOME >> BIOLOGY >> NEWS
Polymer gel can block toxic leakage problem in gene therapy

DURHAM, N.C. -- Duke University biomedical engineers have devised a potentially patentable method to arrest toxic leakages of genetically engineered viruses that have plagued attempts to use gene therapy against cancerous tumors. The problem has been that viruses carrying anti-tumor genes have tended to leak from tumors, proving toxic to other body tissues.

The researchers have developed a biocompatible polymer that briefly changes from a liquid at 39 degrees Fahrenheit to a gel at body temperatures to block most gene-bearing viruses from being diverted through the blood stream to the wrong targets, the scientists reported in research journals.

"With this method we can reduce the misdirected virus dissemination by a factor of 100 to 1,000 times," said Fan Yuan, an associate biomedical engineering professor at Duke's Pratt School of Engineering who led the studies. "That's enough of a reduction to solve the problem."

The work was supported by the National Science Foundation.

According to Yuan, about 66 percent of the 918 gene therapy clinical trials conducted in 24 countries between 1989 and 2004 were aimed at treating cancer.

His interdisciplinary group from the Pratt School and the Duke Medical Center's radiation oncology department studied a preferred kind of anti-cancer gene therapy that uses relatively harmless adenoviruses to infect tumor cells. Once in a targeted tumor, genes in these genetically modified viruses are designed to express their modified genes to manufacture proteins that can either trigger tumor cell death or stimulate the immune system to attack the cancer.

Yuan said he and other Duke researchers have found that, because of the small size of pores in blood vessel walls and other access points, these adenoviruses cannot reach the majority of tumor cells by being injected into the blood stream but instead must be injected directly into tumors themselves.

However, direct intratumoral injectio
'"/>

Contact: Monte Basgall
monte.basgall@duke.edu
919-681-8057
Duke University
18-Nov-2005


Page: 1 2 3 4

Related biology news :

1. Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications
2. Polymer aids in blood clotting, pointing way to new treatment
3. Polymer expert writes text about better, inexpensive ways to create plastic
4. Polymers with copper show promise for implanted sensors
5. Molecule blocks gene, sheds light on liver cancer
6. Negative effects of plastics additive blocked by nutrient supplements
7. MIT researchers probe bones tiny building blocks
8. Blood sugars manufacture limited by building blocks supply
9. Removing a hydrogen fuel-cell roadblock
10. New compound prevents alcoholic behavior, relapse in animals by blocking stress response
11. Drug blocks lethal motor-neuron disease in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/21/2016)... June 21, 2016 NuData Security announced today ... role of principal product architect and that ... of customer development. Both will report directly to ... The moves reflect NuData,s strategic growth in its ... high customer demand and customer focus values. ...
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
Breaking Biology Technology:
Cached News: