HOME >> BIOLOGY >> NEWS
Polymer gel can block toxic leakage problem in gene therapy

DURHAM, N.C. -- Duke University biomedical engineers have devised a potentially patentable method to arrest toxic leakages of genetically engineered viruses that have plagued attempts to use gene therapy against cancerous tumors. The problem has been that viruses carrying anti-tumor genes have tended to leak from tumors, proving toxic to other body tissues.

The researchers have developed a biocompatible polymer that briefly changes from a liquid at 39 degrees Fahrenheit to a gel at body temperatures to block most gene-bearing viruses from being diverted through the blood stream to the wrong targets, the scientists reported in research journals.

"With this method we can reduce the misdirected virus dissemination by a factor of 100 to 1,000 times," said Fan Yuan, an associate biomedical engineering professor at Duke's Pratt School of Engineering who led the studies. "That's enough of a reduction to solve the problem."

The work was supported by the National Science Foundation.

According to Yuan, about 66 percent of the 918 gene therapy clinical trials conducted in 24 countries between 1989 and 2004 were aimed at treating cancer.

His interdisciplinary group from the Pratt School and the Duke Medical Center's radiation oncology department studied a preferred kind of anti-cancer gene therapy that uses relatively harmless adenoviruses to infect tumor cells. Once in a targeted tumor, genes in these genetically modified viruses are designed to express their modified genes to manufacture proteins that can either trigger tumor cell death or stimulate the immune system to attack the cancer.

Yuan said he and other Duke researchers have found that, because of the small size of pores in blood vessel walls and other access points, these adenoviruses cannot reach the majority of tumor cells by being injected into the blood stream but instead must be injected directly into tumors themselves.

However, direct intratumoral injectio
'"/>

Contact: Monte Basgall
monte.basgall@duke.edu
919-681-8057
Duke University
18-Nov-2005


Page: 1 2 3 4

Related biology news :

1. Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications
2. Polymer aids in blood clotting, pointing way to new treatment
3. Polymer expert writes text about better, inexpensive ways to create plastic
4. Polymers with copper show promise for implanted sensors
5. Molecule blocks gene, sheds light on liver cancer
6. Negative effects of plastics additive blocked by nutrient supplements
7. MIT researchers probe bones tiny building blocks
8. Blood sugars manufacture limited by building blocks supply
9. Removing a hydrogen fuel-cell roadblock
10. New compound prevents alcoholic behavior, relapse in animals by blocking stress response
11. Drug blocks lethal motor-neuron disease in mice

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Polymer gel can block toxic leakage problem gene therapy

(Date:7/28/2014)... Earth that are high priorities for conservation in the ... as it has the lowest fraction of its land ... ,refugia, areas of biological diversity that support many ... times of great environmental change. The refugia that do ... , The biggest refugia are in the Amazon, ...
(Date:7/28/2014)... hunter, but the target of his work consists of ... special methods and instruments. Benjamin Hause, an assistant research ... Kansas State University, recently published an article about one ... important find in the United States. , "We had ... it was," Hause said. "We used next-generation sequencing to ...
(Date:7/28/2014)... found that 73 percent of adult survivors of childhood ... syndrome and related health problems by failing to follow ... issue of the journal Cancer . , Almost ... cancer in the study had metabolic syndrome, an umbrella ... abdominal obesity, elevated triglyceride and other abnormalities that often ...
Breaking Biology News(10 mins):Study finds Europe's habitat and wildlife is vulnerable to climate change 2Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3
(Date:7/28/2014)... COLLEGE STATION, Texas , July 28, 2014 /PRNewswire/ ... will be a 177-key, 4-star boutique hotel in the heart ... , Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... the first hotel within ATLAS , The ... mixture of standard rooms and suites, a sleek restaurant and bar, ...
(Date:7/25/2014)... Albany, NY (PRWEB) July 26, 2014 ... Trials Review, H2, 2014" provides data on the ... This report provides elemental information and data relating ... Cerebral Stroke. , View full global Ischemic Stroke ... It includes an overview of the trial numbers ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
(Date:7/25/2014)... California (PRWEB) July 25, 2014 Lawrence ... named to Thomson Reuters list of " The World's ... are part of the 3,000 researchers who were identified ... to recognize those who published the highest-impact work (2002-2012 ... research papers on combustion modeling . , "This ...
Breaking Biology Technology:Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4
Cached News: