HOME >> BIOLOGY >> NEWS
Polymers with copper show promise for implanted sensors

ANN ARBOR, Mich.---Developing chemical sensors that can be placed in the bloodstream or under the skin to continuously monitor oxygen, acidity (pH), or glucose levels is a major challenge for analytical chemists and biomedical engineers. The problem is, the body responds to these foreign objects in ways that interfere with their ability to accurately measure blood chemistry. In the bloodstream, clots form on the surface of implanted sensors or blood vessels contract around them. Sensors implanted under the skin may become walled off by cells that flock to the site as part of the inflammatory response.

A University of Michigan team that previously demonstrated improved accuracy with intravascular sensors that were coated with nitric oxide-releasing polymers has promising preliminary results with a new strategy: creating polymer coatings that generate nitric oxide from components already in the blood. U-M chemistry professor Mark Meyerhoff will discuss the work March 15 at the 229th national meeting of the American Chemical Society in San Diego, Calif.

"The idea we had, when we started working on this problem about eight years ago, was to try to mimic what occurs in the human body to prevent clotting on the walls of your own blood vessels," said Meyerhoff. "Your endothelial cells---the cells that line all of your blood vessels---generate nitric oxide. The nitric oxide produced in this layer of cells diffuses back into the blood vessel walls, where it relaxes surrounding muscle cells and increases blood flow. It also diffuses into the lumen of the blood vessel, where it plays another important role: it inhibits platelet function and prevents platelets from sticking to the surface of the blood vessels."

Over the years, Meyerhoff and collaborators have developed nitric oxide-releasing polymers, then coated sensors with the polymers and implanted the sensors into the arteries of laboratory animals. "We always see an improvement in the acc
'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
15-Mar-2005


Page: 1 2 3

Related biology news :

1. Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications
2. UB scientist discovers novel iron-copper alliance
3. Montana State University researchers to compare Montana, Japanese copper mines
4. MNI researchers find a new role for mitochondria in cellular copper regulation
5. Cancer cells forming blood vessels send their copper to the edge
6. Study illuminates birth defects caused by copper deficiency
7. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
8. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
9. New proteomics research promises to revolutionize biomedical discovery
10. New research holds promise for protecting cancer patients against infertility
11. New approach to pulmonary hypertension shows promise

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... ... February 05, 2019 , ... Amino Labs, a ... with MindFuel, a leading organization in educational science, technology, engineering and math (STEM) ... has pioneered a syn-bio starter kit for teachers – the Amino Labs ...
(Date:2/2/2019)... ... January 31, 2019 , ... ... organization headquartered in Morrisville, NC, providing full, customizable clinical research services across ... to support educational programs for early stage life science entrepreneurs in the ...
(Date:1/25/2019)... ... January 24, 2019 , ... uBiome, the leader ... of Microbiology at the Jackson Laboratory (JAX), to its Scientific Advisory Board. Joining ... will bring to uBiome expertise in skin microbial interactions and probiotic treatments for ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 29, 2019 , ... MabPlex International Ltd ... the global biopharmaceutical and biotechnology industries with sites in China and the United ... global investors lead by China's State Development & Investment Corporation (SDIC) and Shenzhen ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... academia and governmental agencies to discuss best practices for laboratory automation and screening. ... , At this year’s conference, Visikol will be at booth #345 and ...
(Date:1/24/2019)... ... , ... Dr. Douglas Stramel of Advanced Care Veterinary Services in ... for nearly three years. A proponent of Regenerative Medicine, Dr. Stramel has ... using V-PET™ 2016. V-PET™ is a gravity filtration-based platelet therapy kit that produces ...
(Date:1/20/2019)... ... 17, 2019 , ... Consumers are directing healthcare in many ... That's changing as many services now exist for patients to order tests without ... $208 million in 2018, according to Kalorama Information’s new report, The Direct-To-Consumer ...
Breaking Biology Technology:
Cached News: