HOME >> BIOLOGY >> NEWS
Possible brain hormone may unlock mystery of hibernation

The discovery of a possible hibernation hormone in the brain may unlock the mystery behind the dormant state, researchers reported in the April 7, 2006 issue of Cell. Hibernation allows animals from bears to rodents to survive unscathed--in a state of suspended animation--under the harshest of winter conditions.

If the findings in chipmunks are confirmed, the hormone would represent the first essential brain signal governing the seasonal adaptation, according to the researchers.

As hibernation factors endow animals with an incredible ability to cope under otherwise lethal conditions--ratcheting down their metabolic rate to survive on limited energy reserves and withstanding extreme cardiovascular and oxygen stresses--the candidate hormone might also pave the way toward clinical therapies that lend humans the same kind of protection, they added.

The researchers earlier found that concentrations of "hibernation-specific protein" complex (HPc) decline in the blood of hibernating chipmunks. The team now reports evidence that the level of HPc in the brain increases at the onset of hibernation independently of changes in body temperature. Moreover, treatments that block HP activity in the animals' brains cuts hibernation short.

"One of the most curious biological phenomena in mammals is their ability to hibernate circannually, which allows them to survive unusually low body temperatures at or near freezing," said study author Noriaki Kondo of Mitsubishi Kagaku Institute of Life Sciences in Japan.

"Although the functions of HP remain to be clarified, the current observations lead us to propose the involvement of the protein complex in the regulation of energy metabolism and/or biological defenses during hibernation--crucial events for adapting to the severe physiological state," Kondo said.

In the current study, the researchers first demonstrated that hibernation in chipmunks is strictly controlled by an individ
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
6-Apr-2006


Page: 1 2 3

Related biology news :

1. Possible genetic link to schizophrenia identified
2. Possible evidence of cell division, differentiation found in oldest known embryo fossils
3. Possible birthplace of malignant brain tumors identified
4. Possible cause and potential treatment found for aggressive head and neck cancer
5. Invasion of the brain tumors
6. Preclinical study links gene to brain aneurysm formation
7. Gene variant is associated with brain anatomy, clinical course of ADHD
8. Human knowledge is based upon directed connectivity between brain areas
9. A sensory organ, not the brain, differentiates male and female behavior in some mammals
10. Reading ability protects brain from lead exposure
11. Strength of connections between brain regions may affect an adolescents response to peer influence

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Possible brain hormone may unlock mystery hibernation

(Date:11/5/2014)... -Individuals show great diversity in their ability to identify ... greatly differ in their perceptual evaluation of odors, with ... , Sex differences in olfactory detection may ... be connected to one,s perception of smell, which is ... olfactory superiority has been suggested to be cognitive or ...
(Date:11/4/2014)... (November 4, 2014) — Think about the way our ... do neighboring cells know that they are supposed to ... do these tissues find the correct place and alignment? ... these crucial questions. , In a new study, UM ... communicate with their surrounding neighbors, at the head-trunk region. ...
(Date:11/4/2014)... Nov. 4, 2014   Neurotechnology , a ... that the latest version of its fingerprint matching ... Ongoing MINEX evaluation organized by NIST. The ... using the INCITS 378 fingerprint standard template format. ... public tenders in the United States ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
(Date:11/24/2014)... One of the most extensive, widely cited ... is now available to high school and junior college students ... the international society for optics and photonics , announced today ... Digital Library available to high schools for free and ... integral to all areas of life in today’s world,” said ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 Continental ... patient populations into clinical trials at its mid-Atlantic ... , “Continental was created with the idea of ... a fundamental role in medical advances," said Continental's ... syphilis experiment to the immortal cell line of ...
(Date:11/24/2014)... 2014 Deep Research Report on ... professional and in-depth research report on the Adipic ... its definition, classification, application, and industry chain structure ... the international market analysis, including China’s domestic market ... Europe, Asia, China, Japan etc. regions) industry analysis ...
(Date:11/24/2014)... 2014 The new video, “ ... TOLEDO demonstrates how to reduce the number of ... sample panel design can be complicated, requiring multiple ... against corrosion and deposition. Dedicated single and dual ... of panel space. Additionally, installing and maintaining each ...
Breaking Biology Technology:SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2
Cached News: