HOME >> BIOLOGY >> NEWS
Possible genetic link to schizophrenia identified

Several neurological and psychiatric disorders, including schizophrenia, alcoholism, and Parkinsons disease, are associated with changes in the brain that affect the nerves that communicate with each other through the naturally-produced chemical dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. However, very little is known about the function of this protein in humans.

In a study appearing online on February 8 in advance of publication in the March print issue of the Journal of Clinical Investigation, Daniel Weinberger and colleagues from the National Institutes of Health show that the gene that encodes DARPP-32 exhibits genetic variation. One particular variant that increased expression of the mRNA encoding DARPP-32 in the brain was associated with increased performance in a number of cognitive tests, including IQ and memory tests. This variant was also associated with changes in the structure and function of part of the brain known as the neostriatum, as well as changes in the ability of the neostriatum to communicate with the frontal lobe. Importantly, preliminary analysis indicated that this variant was associated with an increased risk of schizophrenia, although further studies will be necessary to confirm this association.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
8-Feb-2007


Page: 1

Related biology news :

1. Possible evidence of cell division, differentiation found in oldest known embryo fossils
2. Possible birthplace of malignant brain tumors identified
3. Possible cause and potential treatment found for aggressive head and neck cancer
4. Possible brain hormone may unlock mystery of hibernation
5. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
6. Does the desire to consume alcohol and tobacco come from our genetic makeup?
7. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
10. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
11. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... Precision Periodontics and Implant ... and LAPIP™ laser treatments. Drs. Hoge and Zalewsky are members of an elite ... and less painful option that produces real results. , "Like many of my ...
(Date:9/22/2017)... ... 2017 , ... The effectiveness of a new wound healing ... in the United States. (clinicaltrials.gov : NCT02973893) , To find out more about ... nearest participating clinic here https://factor-therapeutics.com/clinical-trials/ and discuss your condition with one ...
(Date:9/21/2017)... ... ... Dr. Greg Leyer, Chief Scientific Officer of UAS Labs, will be presenting at ... in the Probiotics Resource Center, Mandalay Bay Expo Hall. , “I am very ... shown impressive data in areas outside the gut including heart health, Vitamin D status, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Colpitts Clinical ... of the portal includes new features that facilitate streamlined and compliant communication, file ... remain at the forefront of medical advancements, they rely on efficiencies to help ...
Breaking Biology Technology:
Cached News: