HOME >> BIOLOGY >> NEWS
Possible genetic link to schizophrenia identified

Several neurological and psychiatric disorders, including schizophrenia, alcoholism, and Parkinsons disease, are associated with changes in the brain that affect the nerves that communicate with each other through the naturally-produced chemical dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. However, very little is known about the function of this protein in humans.

In a study appearing online on February 8 in advance of publication in the March print issue of the Journal of Clinical Investigation, Daniel Weinberger and colleagues from the National Institutes of Health show that the gene that encodes DARPP-32 exhibits genetic variation. One particular variant that increased expression of the mRNA encoding DARPP-32 in the brain was associated with increased performance in a number of cognitive tests, including IQ and memory tests. This variant was also associated with changes in the structure and function of part of the brain known as the neostriatum, as well as changes in the ability of the neostriatum to communicate with the frontal lobe. Importantly, preliminary analysis indicated that this variant was associated with an increased risk of schizophrenia, although further studies will be necessary to confirm this association.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
8-Feb-2007


Page: 1

Related biology news :

1. Possible evidence of cell division, differentiation found in oldest known embryo fossils
2. Possible birthplace of malignant brain tumors identified
3. Possible cause and potential treatment found for aggressive head and neck cancer
4. Possible brain hormone may unlock mystery of hibernation
5. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
6. Does the desire to consume alcohol and tobacco come from our genetic makeup?
7. Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
10. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
11. Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/10/2016)... PUNE, India , March 10, 2016 ... to a new market research report "Identity and Access ... SSO, & Audit, Compliance, and Governance), by Organization Size, ... Forecast to 2020", published by MarketsandMarkets, The market is ... to USD 12.78 Billion by 2020, at a Compound ...
(Date:3/8/2016)...   Valencell , the leading innovator in ... secured $11M in Series D financing. The investment ... fund being launched by UAE-based financial services company ... TDF Ventures and WSJ Joshua Fund. Valencell plans ... growth and accelerate its pioneering innovation in accurate ...
(Date:3/2/2016)... 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ... "Global Biometrics as a Service Market 2016-2020" ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced the ... a Service Market 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... RESEARCH TRIANGLE PARK, N.C. , April ... UTHR ) announced today that Martine Rothblatt , ... will provide an overview and update on the company,s ... Health Care Conference. The presentation will take ... Eastern Time, and can be accessed via a live ...
(Date:4/27/2016)... ... 27, 2016 , ... Global Stem Cells Group CEO Benito Novas ... founder of GSCG affiliate Kimera Labs in Miami. , In 2004, Ross received his ... transplantation for hematologic disorders and the suppression of graft vs. host disease (GVHD) under ...
(Date:4/26/2016)... ... April 26, 2016 , ... BaseHealth , the ... the company as Chief Business Officer. Arianpour, a genomics pioneer and visionary commercial ... was most recently Chief Commercial Officer of Pathway Genomics. He has held senior ...
(Date:4/26/2016)... Frederick, MD (PRWEB) , ... April 26, 2016 , ... ... of a $1.8M Series A round of financing. Healthy investor interest drove significant ... a portfolio of generic biologics, known as biosimilars, to the advanced preclinical stages. , ...
Breaking Biology Technology:
Cached News: