HOME >> BIOLOGY >> NEWS
Power-boosting signal in muscle declines with age

As people age, they may have to exercise even harder to get the benefits afforded to younger folk. That's the suggestion of a report in the February issue of the journal Cell Metabolism, published by Cell Press, showing that a signal that gives muscles a kind of metabolic boost in response to exercise is blunted in older animals.

The researchers found that so-called AMP-activated protein kinase (AMPK) slows down in the skeletal muscle of 2-year-old rats relative to 3-month-old rats. A chief regulator of whole-body energy balance, AMPK in skeletal muscle stimulates the oxidation of fatty acids and the production, or biogenesis, of power-producing mitochondria that burn fat and fuel cells, according to the researchers.

The new findings might help to explain "what happens as we age," said Gerald I. Shulman, a Howard Hughes Medical Institute investigator at Yale University School of Medicine.

Earlier studies have shown that, in comparison to 20-year-old adults, even lean and healthy people in their seventies show a higher incidence of fat buildup in their muscle and livers and a deficiency in mitochondrial function, Shulman explained. These metabolic shifts have been implicated in the increased prevalence of insulin resistance and type 2 diabetes that occurs with aging.

"The message of this paper is that, with aging, the AMPK pathway has reduced activity," Shulman said. "So, one probably has to work harder to maintain the same level of fat oxidation and mitochondrial biogenesis in muscle."

The number of mitochondria within muscle largely determines its metabolic capacity. The mitochondrial composition of fibers in different muscles corresponds to the jobs that they do, and muscle can be "reprogrammed" through exercise.

For example, Shulman said, the skeletal muscles of marathon runners typically have much greater mitochondrial content and a greater capacity to burn fat. Those properties can most likely be a
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
6-Feb-2007


Page: 1 2

Related biology news :

1. Increase in creeping vines signals major shift in southern US forests
2. Insulin sensitizer also serves as energy-conserving signal to the brain
3. Endosome-mediated signaling in plants
4. University of Colorado invention may allow thirsty crops to signal farmers
5. Banding together: RAS signaling of circadian output
6. Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
7. Blood test may help signal tumors remission, return in throat cancer patients
8. Research identifies protein that signals flowering in squash plants
9. Climate change signal detected in the Indian Ocean
10. Nondanger signal lowers immune reactions
11. Scientists report new take on sexual signaling

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/1/2020)... ... 2020 , ... Catalent, a global leader in clinical supply ... facility in Minakuchi, located in the Shiga prefecture of Japan. , Operating in ... new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, serving both ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... development services, today announced that the company has received ISO9001:2015 certification for ... diagnostics, and research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... ... manufacturing capability in Wuxi, China. The new plant operation will provide the local ... advanced technology. , “This facility will improve the flexibility of our offerings ...
(Date:8/15/2020)... ... August 13, 2020 , ... Inc. magazine ... the most prestigious ranking of the nation’s fastest-growing private companies. The list represents ... dynamic segment—its independent small businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, and many ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... firm, is making available for free its new white paper – Simulated ... simulation testing into today’s biologics licensing application (BLA). In response, Modality Solutions ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... industries, announces it has closed on the purchase of greenfield for a new, ... TX and includes over 21 acres in the initial acquisition, with an option ...
Breaking Biology Technology:
Cached News: