Prediction models help identify increased risk of gene mutation linked with colorectal cancer

Hereditary Colorectal Cancer

In an accompanying editorial, James M. Ford, M.D., and Alice S. Whittemore, Ph.D., of the Stanford University School of Medicine, Stanford, Calif., comment on the studies in this week's JAMA concerning the development of predictive models for colorectal cancer.

"In summary, these prediction rules should form very useful tools for clinicians and their patients, as well as for epidemiologists who wish to assess both the magnitude of the hereditary nonpolyposis colorectal cancer problem and the potential usefulness of preventive efforts. What are the next steps? Evaluation of all [these] rules using a single data set would be helpful and allow for a direct comparison of the models. Studies using population-based data would be preferable, to assess the performance of the rule among individuals with little or no family history of the Lynch syndrome malignancies. Since the rules were developed and evaluated using samples primarily composed of white individuals with European ancestry, there also is great need to evaluate the performances of these rules when applied to ethnic minorities, as the prevalence and penetrance of Lynch syndrome is poorly understood in nonwhite populations," they write. (JAMA. 2006;296:1521-1523. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: Financial disclosures none reported.


Contact: Janet Haley Dubow
JAMA and Archives Journals

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