HOME >> BIOLOGY >> NEWS
Prediction of a prokaryotic RNA-silencing system

Researchers have used computational methods to predict what could be a prokaryotic RNA-silencing mechanism similar to the eukaryotic RNA- interference system. A study published today in the open access journal with a novel system of peer review, Biology Direct, provides the first strong evidence that a type of tandem repeats found in archaea and bacteria, the Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR), might act in conjunction with the CRISPR-associated (cas) family of genes as a defence mechanism against phage and plasmid RNA. A number of Cas proteins are shown to contain domains that suggest a functional similarity to eukaryotic proteins involved in the eukaryotic RNA-interference system.

Kira Makarova and other members of a group led by Eugene Koonin, from the National Institutes of Health, Bethesda, USA, carried out a comparative genomic analysis of CRISPR and cas genes in archaeal and bacterial genome sequences retrieved from National Center for Biotechnology Information (NCBI) databases.

Makarova et al. identified a number of cas genes that are always located close to CRISPR clusters and encode proteins potentially involved in RNA-processing mechanisms such as unwinding and cleaving. These proteins might be functionally similar to eukaryotic enzymes involved in the RNA-interference system Makarova et al. identify an analog to the eukaryotic RNAi protein Dicer and several potential analogs to the eukaryotic RNAi protein Slicer. But they are not homologous to Dicer and Slicer as they have no sequence similarity with them.

It has been shown that a proportion of inserts in CRISPR units are similar to fragments of viral or plasmid genomes. Makarova et al. extend these observations and propose that all CRISPR inserts are derived from viruses or plasmids but this is not immediately obvious because most of these agents are still unknown. They speculate that the inserts are transcribed and silence phage or plasmid seque
'"/>

Contact: Juliette Savin
press@biomedcentral.com
44-207-631-9931
BioMed Central
15-Mar-2006


Page: 1 2

Related biology news :

1. Prediction of graft-versus-host disease by gene-expression profiling of donors and more
2. Prediction models help identify increased risk of gene mutation linked with colorectal cancer
3. Prediction of gene function in mammals
4. Bursts of waves drive immune system soldiers toward invaders
5. New system of wastewater treatment could reduce the size of treatment plants by half
6. Viewing ecosystems from above
7. Forecasting system provides flood warnings to vulnerable residents of Bangladesh
8. Immune system escape hatch gives cancer cells traction
9. Link between immune system and mammary gland could shed new light on breast cancer
10. Researchers discover method for identifying how cancer evades the immune system
11. A new system for collaboration in cell communication

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2019)... ... February 12, 2019 , ... ... under its new name, KEYLEAF. The company will also shift focus from ... extracts and ingredients as finished products under the new KEYLEAF brand. KEYLEAF ...
(Date:2/11/2019)... ... February 11, 2019 , ... Allotrope ... completing the phased release of the Allotrope™ Framework for standardizing scientific data and ... previously released Allotrope™ Data Format (ADF) and application programming interfaces (APIs), and the ...
(Date:2/6/2019)... ... 05, 2019 , ... Amino Labs, a leading developer of ... leading organization in educational science, technology, engineering and math (STEM) to expand its ... a syn-bio starter kit for teachers – the Amino Labs Educators Starter Kit ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... 29, 2019 , ... K&R Negotiations announced today that Mladen Kresic, CEO and ... titled: Six Ways to Shorten the Sales Cycle : Reduce Complexity and Increase ... BrightTALK network. , Negotiation expert Kresic will discuss the realities of today’s complex ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... pharma, academia and governmental agencies to discuss best practices for laboratory automation and ... 4-6. , At this year’s conference, Visikol will be at booth #345 ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... international tasting 5StarWines to promote and give recognition to producers whose work focuses ... Walls selection takes place in Verona, Italy, contemporaneously to the 5StarWines blind tasting ...
(Date:1/24/2019)... ... ... Controlled Contamination Services is pleased to announce three exciting new additions to its ... members will support its growing operation across the US and will be a vital ... addition will enable CCS to widen its reach and provide enterprise wide solutions within ...
Breaking Biology Technology:
Cached News: