Prediction of Graft-Versus-Host Disease by Gene-Expression Profiling of donors
Graft-versus-host disease is a complication of allogeneic hematopoietic cell transplantation, which results from recognition of recipient antigens by immune T cells from the donor. Two papers published this week investigate how graft versus host disease might be predicted after hematopoietic cell transplantation. In the first paper Prediction of Graft-Versus-Host Disease by Gene-Expression Profiling of Donors Claude Perreault and colleagues from the University of Montreal tested whether some donors may react more strongly against recipient cells than others. Using microarrays, they measured the gene-expression profiles of CD4+ and CD8+ T cells from 50 donors and were able to show that donor gene-expression profile in these cells had a strong influence on the occurrence of graft-versus-host disease in the recipient.
Citation: Baron C, Somogyi R, Greller LD, Rineau V, Wilkinson P, et al. (2006) Prediction of graft-versus-host disease in humans by donor gene-expression profiling. PLoS Med 4(1): e23.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040023
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-perreault.pdf
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MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation