HOME >> BIOLOGY >> NEWS
Prediction of graft-versus-host disease by gene-expression profiling of donors and more

Prediction of Graft-Versus-Host Disease by Gene-Expression Profiling of donors

Graft-versus-host disease is a complication of allogeneic hematopoietic cell transplantation, which results from recognition of recipient antigens by immune T cells from the donor. Two papers published this week investigate how graft versus host disease might be predicted after hematopoietic cell transplantation. In the first paper Prediction of Graft-Versus-Host Disease by Gene-Expression Profiling of Donors Claude Perreault and colleagues from the University of Montreal tested whether some donors may react more strongly against recipient cells than others. Using microarrays, they measured the gene-expression profiles of CD4+ and CD8+ T cells from 50 donors and were able to show that donor gene-expression profile in these cells had a strong influence on the occurrence of graft-versus-host disease in the recipient.

Citation: Baron C, Somogyi R, Greller LD, Rineau V, Wilkinson P, et al. (2006) Prediction of graft-versus-host disease in humans by donor gene-expression profiling. PLoS Med 4(1): e23.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040023

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-perreault.pdf

CONTACT:

Claude Perreault
University of Montreal
IRIC
P.O. Box 6128, Station Centre-Ville
Montreal, Quebec H3C 3J7 Canada
+1 514-343-6126
+1 514-343-5839 (fax)
c.perreault@videotron.ca


MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation

In the second paper, MHC Haplot
'"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
29-Jan-2007


Page: 1 2 3

Related biology news :

1. Prediction models help identify increased risk of gene mutation linked with colorectal cancer
2. Prediction of a prokaryotic RNA-silencing system
3. Prediction of gene function in mammals
4. Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
5. Gilbert Foundation and American Fed for Aging Research award grants on Alzheimers disease
6. Antioxidant overload may underlie a heritable human disease
7. Female gender provides an advantage in renal diseases
8. The female advantage in kidney disease does not extend to diabetic women
9. Link between sunspots, rain helps predict disease in east Africa
10. Cornell scientists link E. coli bacteria to Crohns disease
11. Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2019)... ... October 03, 2019 , ... Mount Sinai researchers have discovered ... down from one generation to the next. In a study published in Nature Structural ... of this enzyme, leading to cancers and other diseases. , “DNA polymerase delta serves ...
(Date:9/30/2019)... ... September 30, 2019 , ... Foresight Institute, a leading think ... technologies, announced the winners for the 2019 Foresight Institute Feynman Prizes. These are ... nanotechnology/molecular manufacturing. , Established in 1993 and named in honor of pioneer physicist ...
(Date:9/30/2019)... (PRWEB) , ... September 30, ... ... leading think tank, research, and public interest organization focused on molecular manufacturing ... Student Prize. , The Award recognizes the College graduate or undergraduate student ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... ... October 10, 2019 , ... R3 Stem Cell announces it has ... October 18-19th, 2019 in Las Vegas with spots still open. , The speaker, Dr. ... several Ivy League universities including Cornell, Harvard and Dartmouth. He currently serves as the ...
(Date:10/8/2019)... ... October 08, 2019 , ... Today, Massachusetts stem cell biotechnology company Asymmetrex ... Like the company’s precursor patent, approved in the U.S. in 2017, the new patent ... Asymmetrex now markets the technology in the U.S. as the AlphaSTEM Test™. ...
(Date:10/3/2019)... MURRIETA, Calif. (PRWEB) , ... October 02, 2019 , ... ... its business opportunity to investors and venture capital companies in Silicon Valley at a ... to 8:30 pm. The event will be held at the JJ Lake Business Center ...
(Date:9/30/2019)... ... September 30, 2019 , ... The September 2019 edition ... , is now available online on the company’s global website. The Bridge features ... diffraction, fluorescence and imaging, and presents articles, scientific papers and news reports. ...
Breaking Biology Technology:
Cached News: