HOME >> BIOLOGY >> NEWS
Preeclampsia, fetal development problems may be linked to low levels of hormone

CHAPEL HILL -- New research from the University of North Carolina at Chapel Hill ties low levels of a hormone secreted by the uterus and embryos to problems with pregnancy and fetal development.

The findings also suggest that the hormone, adrenomedullin, plays a key role in maternal susceptibility to preeclampsia, a serious pregnancy complication that occurs in the third trimester. Preeclampsia affects roughly one in fifteen pregnant women and is the leading cause of death among expectant mothers.

The UNC researchers demonstrated that pregnant mice with low adrenomedullin levels had reduced litter sizes, and while embryos implanted normally in the uterus, their spacing was overcrowded and resulted in poor growth. Because the low hormone levels were caused by a genetic mutation affecting adrenomedullin production, similar genetic changes could be linked to problems in human pregnancy, the researchers said.

"Our study provides the first genetic evidence to suggest that a modest reduction in human adrenomedullin expression during pregnancy may cause profound defects during pregnancy," said Dr. Kathleen M. Caron, senior study author and an assistant professor in the departments of cell and molecular physiology and genetics at the UNC School of Medicine.

Among the potential problems are poor implantation of the embryo, failure of the placenta to establish blood flow between mother and fetus and restricted fetal growth, Caron said. "The clinical implications are that women who have mutations in the gene responsible for expressing adrenomedullin might have greater susceptibility to these pregnancy problems, including preeclampsia."

The study was published online Sept. 14 in the Journal of Clinical Investigation and will appear in the Oct. 2 print edition.

Discovered in 1993, adrenomedullin is a powerful blood vessel dilator that is essential for life. Secreted by cells throughout the body, it is involved in m
'"/>

Contact: L. H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
18-Sep-2006


Page: 1 2 3

Related biology news :

1. Inflammation may cause preterm labor and fetal deaths
2. U-M team identifies gene that regulates blood-forming fetal stem cells
3. Common environmental chemicals in diet affect fetal ovarian development
4. Pregnant moms exposure to flu vaccine kick-starts fetal immune system
5. Endogenous cannabinoids linked to fetal brain damage imposed by maternal cannabis use
6. Cholesterol could be key to treating fetal alcohol syndrome
7. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
8. Epilepsy drug poses high risk for fetal death and birth defects
9. Early fetal gender test demands rapid ethical policymaking
10. New procedure safer for detecting fetal anemia
11. Major findings on fetal research to be unveiled at University of Leicester

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2019)... ... April 30, 2019 , ... Philadelphia intellectual ... to announce that Gunes Bender, Ph.D., a registered patent agent, has joined the ... his new role, Bender provides technical support and scientific expertise in the pharmaceutical ...
(Date:4/27/2019)... ANGELES (PRWEB) , ... April ... ... (SDi) flagship market research study " 2019 Global Assessment Report: The Laboratory ... different product categories is presented in 10 sections that include chromatography, life ...
(Date:4/25/2019)... ... , ... In recent years the neurocognitive effects of treatments ... cases the magnitude of these deficits and the long-term impact on cognitive maturation ... may impact developmental trajectories, and patients are often so unwell at the time ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... ... 2019 , ... Frank is an albino, deaf Great Dane. His owners rescued him when he ... health issues. Despite his hearing impairment, he was always an active and playful pup. Frank ... day, every day. As the two grew, playtime became rougher and Frank ended up injuring ...
(Date:4/16/2019)... ... April 16, 2019 , ... Fulcrum Biometrics , a ... Bank South Pacific (BSP), the largest regionally owned bank in the South Pacific, ... contract to deliver a fingerprint-based Know Your Customer (KYC) banking solution that is ...
(Date:4/10/2019)... ... , ... After more than three months of renovation, Lajollacooks4u is set to ... appliances and modern lighting and fixtures, and will provide additional workspace for the many ... growth in the demand for our team-building events and cooking classes over the last ...
(Date:4/8/2019)... SOUTH JORDAN, Utah and BOSTON (PRWEB) , ... ... ... leader in delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the ... provides integration to an unprecedented range of business and contact-orientated applications while ...
Breaking Biology Technology:
Cached News: