Preeclampsia, fetal development problems may be linked to low levels of hormone

ore than a dozen physiological functions such as metabolism, heart rate control, gastric control, thirst and appetite control, stress response, blood vessel growth, antibacterial activity and nerve transmission.

The hormone also plays a role in a number of diseases and cardiovascular conditions. For example, blood levels of adrenomedullin double in cancer, kidney failure, congestive heart failure, hypertension and diabetes. According to Caron, one of the greatest increases occurs during the course of a normal pregnancy, when the placenta secretes adrenomedullin levels reach four to five times higher than normal by the third trimester before rapidly returning to pre-pregnancy values after delivery.

But in women who experience complications such as preeclampsia, spontaneous abortion, and gestational diabetes, hormone levels do not increase as they normally would in pregnancy. "It's possible that the inability to increase adrenomedullin during pregnancy might be a cause of preeclampsia and other problems," Caron said.

Caron, who has studied adrenomedullin's role in the body for several years, first noticed the link between the hormone and fertility while working as a postdoctoral researcher with UNC professor Dr. Oliver Smithies. Caron discovered that mice with a genetic mutation causing a 50 percent reduction in adrenomedullin levels had poor fertility and small litter sizes.

Caron's latest research establishes that reduced litter sizes are due to low adrenomedullin levels in the mother and not the father. The study also found that although embryos implanted normally, their spacing in the wall of the mouse uterus was "overcrowded," which was associated with poorer subsequent growth. This overcrowding also was linked to abnormal placentas and a high rate of twinning.

The UNC researchers showed that both mother and embryo make an effort to increase the level of adrenomedullin at the embryo's implantation site in the u

Contact: L. H. Lang
University of North Carolina School of Medicine

Page: 1 2 3

Related biology news :

1. Inflammation may cause preterm labor and fetal deaths
2. U-M team identifies gene that regulates blood-forming fetal stem cells
3. Common environmental chemicals in diet affect fetal ovarian development
4. Pregnant moms exposure to flu vaccine kick-starts fetal immune system
5. Endogenous cannabinoids linked to fetal brain damage imposed by maternal cannabis use
6. Cholesterol could be key to treating fetal alcohol syndrome
7. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
8. Epilepsy drug poses high risk for fetal death and birth defects
9. Early fetal gender test demands rapid ethical policymaking
10. New procedure safer for detecting fetal anemia
11. Major findings on fetal research to be unveiled at University of Leicester

Post Your Comments:

(Date:6/4/2019)... , ... June 04, 2019 , ... ... of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% from ... with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... ... Lajollacooks4u is delighted to announce it has been named as one of ... only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as well ... qualify for the Certificate of Excellence –- an award that only 10 percent of ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... testing company, and Mayo Clinic, have documented significant differences in the prevalence of ... and ethnic populations compared to non-Hispanic White women. Results will be presented at ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... A study ... efficient delivery system for the sustained release of human placental stem cell (HPSC)-derived ... was able to deliver CM into the injured kidney, where it helped restore ...
(Date:5/15/2019)... ... 15, 2019 , ... Milton Hershey School® has named William Charles Ballough Harding ... biomedical industry, where he is changing lives by creating solutions to global healthcare challenges ... the vision of our founders – Milton and Catherine Hershey – who always hoped ...
(Date:5/14/2019)... LA JOLLA, Calif. (PRWEB) , ... May 14, 2019 , ... ... announces an office expansion, effectively doubling its space from 2,500 to 5,000 square feet. ... SneakPeek Early Gender DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The ...
(Date:5/4/2019)... Brazil (PRWEB) , ... May 03, 2019 , ... ... given by the President of the Dakila Pesquisas Association, the scientist and ufologist ... Councilmen 2019, in Brasília (DF). Urandir detailed the results of some research carried ...
Breaking Biology Technology:
Cached News: