HOME >> BIOLOGY >> NEWS
Preeclampsia, fetal development problems may be linked to low levels of hormone

ore than a dozen physiological functions such as metabolism, heart rate control, gastric control, thirst and appetite control, stress response, blood vessel growth, antibacterial activity and nerve transmission.

The hormone also plays a role in a number of diseases and cardiovascular conditions. For example, blood levels of adrenomedullin double in cancer, kidney failure, congestive heart failure, hypertension and diabetes. According to Caron, one of the greatest increases occurs during the course of a normal pregnancy, when the placenta secretes adrenomedullin levels reach four to five times higher than normal by the third trimester before rapidly returning to pre-pregnancy values after delivery.

But in women who experience complications such as preeclampsia, spontaneous abortion, and gestational diabetes, hormone levels do not increase as they normally would in pregnancy. "It's possible that the inability to increase adrenomedullin during pregnancy might be a cause of preeclampsia and other problems," Caron said.

Caron, who has studied adrenomedullin's role in the body for several years, first noticed the link between the hormone and fertility while working as a postdoctoral researcher with UNC professor Dr. Oliver Smithies. Caron discovered that mice with a genetic mutation causing a 50 percent reduction in adrenomedullin levels had poor fertility and small litter sizes.

Caron's latest research establishes that reduced litter sizes are due to low adrenomedullin levels in the mother and not the father. The study also found that although embryos implanted normally, their spacing in the wall of the mouse uterus was "overcrowded," which was associated with poorer subsequent growth. This overcrowding also was linked to abnormal placentas and a high rate of twinning.

The UNC researchers showed that both mother and embryo make an effort to increase the level of adrenomedullin at the embryo's implantation site in the u
'"/>

Contact: L. H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
18-Sep-2006


Page: 1 2 3

Related biology news :

1. Inflammation may cause preterm labor and fetal deaths
2. U-M team identifies gene that regulates blood-forming fetal stem cells
3. Common environmental chemicals in diet affect fetal ovarian development
4. Pregnant moms exposure to flu vaccine kick-starts fetal immune system
5. Endogenous cannabinoids linked to fetal brain damage imposed by maternal cannabis use
6. Cholesterol could be key to treating fetal alcohol syndrome
7. Eye movement tasks can be used to assess fetal alcohol spectrum disorders
8. Epilepsy drug poses high risk for fetal death and birth defects
9. Early fetal gender test demands rapid ethical policymaking
10. New procedure safer for detecting fetal anemia
11. Major findings on fetal research to be unveiled at University of Leicester

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2020)... LOS ALAMOS, N.M. (PRWEB) , ... April 28, 2020 , ... ... some of the world’s biggest challenges in agriculture and aquaculture with the mission of ... eight presenters at the 2020 F&A Next ' Next Heroes in Food- and Ag-Tech ...
(Date:4/30/2020)... ... April 29, 2020 , ... At the start of 2020 ... solutions for a wide range of industries including pharmaceutical and biopharmaceutical manufacturing, healthcare, ... the new decade, it was clear to company leadership that they would have ...
(Date:4/26/2020)... ... April 23, 2020 , ... SECO , a leading ... Growth managed by Fondo Italiano d’Investimento SGR, today announced a partnership with IBD, ... Respira, a new non-invasive pulmonary ventilator created in response to the current health ...
Breaking Biology News(10 mins):
(Date:5/30/2020)... YORK (PRWEB) , ... May 29, 2020 , ... ... of Chief Medical Officer 360°, the first newsletter solely dedicated to the unique ... capture a wide range of perspectives on the responsibilities, problem-solving, best practices and ...
(Date:5/21/2020)... Prairie, MN (PRWEB) , ... May 19, 2020 , ... ... to help patients get dental implants and bone grafting through PIEZOSURGERY® technology. ... tissues. This is often used to prepare a patient for dental implants, especially when ...
(Date:5/15/2020)... ... May 14, 2020 , ... This new service offers clients a way to ... answered quickly as the need arises. Lachman’s OnCall SMEs have extensive knowledge of a ... , Lachman OnCall™ SMEs are available normal business hours Monday through Friday from ...
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages ... providing little or no information on the drug’s mechanism of action (MOA). Gene ... compounds by measuring the activity of molecular pathways. This information can complement phenotypic ...
Breaking Biology Technology:
Cached News: