HOME >> BIOLOGY >> NEWS
'Pregnant' protein-coding genes carry RNA 'babies'

BEIJING, China Scientists from the Chinese Academy of Sciences have performed a comprehensive analysis of small, non-protein-coding RNAs in the model nematode, C. elegans. They characterize 100 heretofore-undescribed transcripts, including two novel classes; they provide insights into the genomic structure and transcriptional regulation of non-coding RNAs; and they underscore the importance of non-coding RNAs in nematode development. Their work appears this month in the journal Genome Research.

"The significance of non-protein-coding RNAs as central components of various cellular processes has risen sharply over the recent years," explains Prof. Runsheng Chen, principal investigator on the study. Excluding microRNAs (miRNAs), or small transcripts that have recently received widespread attention and are known to play important roles in transcriptional regulation, small non-coding RNAs (or ncRNAs) in C. elegans have not been extensively investigated until now.

Using a new, high-throughput procedure to clone small, full-length ncRNAs, Chen's laboratory isolated and characterized 161 unique transcripts. A major advantage of the new cloning procedure is that it achieves an extraordinarily high detection rate for ncRNAs by current standards. "Studies published over recent years have only been able to reach a detection rate of about 3%, but our method reached a detection rate of 30% a 10-fold increase in cloning efficiency," explains Chen. "It's like going from a Model T Ford to a Ferrari in one fell swoop!"

Of the 161 transcripts detected by Chen's group, 100 were novel and 61 were previously known or predicted. Among the 100 novel genes, 30 had no known function, whereas 70 belonged to the ubiquitous class of small nucleolar RNAs (snoRNAs). Based on sequence and structural features, Chen and his colleagues were able to classify more than half of the 30 unknown RNAs into two new categories: stem-bulge RNAs (
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4013
Cold Spring Harbor Laboratory
9-Jan-2006


Page: 1 2

Related biology news :

1. Interaction of just 2 genes governs coloration patterns in mice
2. Gene regulation, not just genes, is what sets humans apart
3. Study finds gender differences in renal and other genes contributing to blood pressure
4. New databases put wings on search for bipolar risk genes
5. Research teams uncover risk genes for multiple sclerosis
6. Risk genes for multiple sclerosis uncovered
7. Sour taste make you pucker? It may be in your genes
8. U-M, Israeli scientists report major advance in search for genes associated with colon cancer
9. Rapid evolution of defense genes in plants may produce hybrid incompatibility
10. Alcohol abuse is in the genes
11. St. Jude study shows genes play an unexpected role in their own activation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... ... April 23, 2019 , ... Leak Detection Associates, the ... Biotechnology, Medical Device and Food Packaging Industries’ is pleased to announce the completion ... Jersey. The new facility was custom designed to meet enhanced manufacturing capabilities that ...
(Date:4/25/2019)... ... April 23, 2019 , ... In ... in the scientific literature. However, in many cases the magnitude of these deficits ... a particularly challenging population, given neurocognitive effects may impact developmental trajectories, and patients ...
(Date:4/25/2019)... (PRWEB) , ... April 24, 2019 , ... ... Human Services Secretary Alex Azar today, a broad collective of 62 individual scientists, ... the American Society of Gene & Cell Therapy (ASGCT), across industry and academia ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 14, 2019 , ... Gateway Genomics , a leading ... space from 2,500 to 5,000 square feet. , “This past year has seen ... says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly ...
(Date:5/7/2019)... ... May 06, 2019 , ... "The new Liquid ... of repositories being asked to store cellular products being used in adoptive ... who are world leaders, who have shared their expertise in building and managing ...
(Date:5/4/2019)... ... May 03, 2019 , ... ... of the Diopsys® ffERG/Photopic Negative Response vision test, a new full ... 2050, it is estimated that 6.3 million Americans will have glaucoma, with black ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
Breaking Biology Technology:
Cached News: