HOME >> BIOLOGY >> NEWS
Premature births from inflammation and infection rapidly detected by proteomics technology

A combination of four proteins that result from inflammation and infection and lead to premature birth can be rapidly and accurately detected in the amniotic fluid of pregnant women using proteomics technology, Yale researchers report in two studies in the February issue of British Journal of Obstetrics and Gynecology.

Using proteomics science, the Yale team, in collaboration with two other academic institutions, developed a novel method called MR scoring to discriminate healthy from diseased women in whom preterm delivery is impending and the health of the fetus is in danger. MR scoring relies on identification of a group of proteins that serve as biomarkers characteristic to women who will deliver preterm. The proteins detected are Human neutrophil defensin 1, Human neutrophil defensin 2, Calgranulin C and Calgranulin A.

"We are probably at a turning point in the history of preterm labor diagnosis," said Irina Buhimschi, M.D., research scientist in the Department of Obstetrics & Gynecology and Reproductive Sciences. "While many proteins are present in the amniotic fluid, not all are biomarkers with diagnostic significance."

About 50 percent of women who deliver prematurely have evidence of inflammation in the amniotic fluid. In the current study, Buhimschi and co-authors analyzed stored samples of amniotic fluid from 107 women, some diagnosed with rupture of the membranes or twins and eventually delivered prematurely. The sensitivity and specificity of the MR score in identifying women who had infection and inflammation and delivered earlier reached 100 percent. The four biomarkers are necessary and sufficient to separate between sick and healthy patients.

Buhimschi said the current "gold standard" for infection consists of amniotic fluid culture, which takes days to obtain results. A proteomic diagnostic test for infection and inflammation could probably be performed much faster than the current available laboratory tests. Other cu
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
4-Feb-2005


Page: 1 2

Related biology news :

1. Premature births may be linked to seasonal levels of pesticides and nitrates in surface water
2. Noninvasive screening in early pregnancy reduces Downs births by 50 percent
3. Rapid syphilis testing in Haiti will prevent congenital disease and stillbirths
4. Difficult births in obese women due to uterus failure
5. Pitt study notes decline in male births in the US and Japan
6. Improving outcomes in premature births
7. African-Americans at increased risk for earlier preterm births
8. Ozone levels may raise risk of underweight births
9. New research on mulitple vs single births may offer new approaches for infertility
10. Penn researchers discover how key protein stops inflammation
11. Gene variations directly link inflammation to an increased risk for lung cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... The Blavatnik ... Winners and six Finalists of the 2017 Blavatnik Regional Awards for Young Scientists. ... Foundation and administered by the New York Academy of Sciences to honor the ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
Breaking Biology Technology:
Cached News: