HOME >> BIOLOGY >> NEWS
Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns

Researchers at the University of Edinburgh in the United Kingdom have found that, as for rodents and other nonprimates, prenatal exposure of nonhuman primate African vervet monkeys (Chloroceus aethiops) to glucocorticoids has long-lasting deleterious effects on cardiovascular, metabolic, and neuroendocrine function.

Glucocorticoids are still widely used in obstetric practice. So, Jonathan Seckl and colleagues set out to determine the relevance to human pregnancy of rodent and nonprimate data indicating that prenatal exposure to glucocorticoids (through either the administration of dexamethasone or severe maternal stress) has long-lasting deleterious effects. In the study, which appears online on March 22 in advance of publication in the April print issue of the Journal of Clinical Investigation, they show that although the birth weight of offspring born to nonhuman primate African vervet monkeys treated with dexamethasone from mid-gestation onward did not differ from that of offspring born to untreated animals, the high levels of prenatal dexamethasone impaired postnatal growth, impaired glucose-insulin homeostasis, increased blood pressure 12 months after birth, and increased the production of cortisol in response to mild stress. These data suggest that both repeated glucocorticoid therapy and severe maternal stress late in gestation are likely to have long-term deleterious effects on developing human fetuses.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
22-Mar-2007


Page: 1

Related biology news :

1. Prenatal stress keeps infants, toddlers up at night, study says
2. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
3. Prenatal toxicity linked to immune dysfunctions in later life
4. Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring
5. Prenatal cocaines lasting cellular effects
6. Prenatal alcohol exposure appears to increase an infants stress response
7. Prenatal vitamins may reduce risk of brain tumors in children
8. Prenatal health strongly influences future economic success
9. Prenatal nicotine exposure reduces breathing response of newborns...
10. Prenatal genistein in soy reduces obesity in offspring
11. Prenatal pesticide exposure and high blood pressure and a decreased ability to copy shapes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC ... services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ... patients with severe COVID-19. This is the first study of an XPO1 inhibitor ...
(Date:6/23/2020)... , ... June 22, 2020 , ... The field of ... ligand binding assays (LBA) have dominated this area. However, the use of mass spectrometry ... , This now necessitates the question “How do you choose which approach to use ...
(Date:6/19/2020)... ... June 16, 2020 , ... The director of stem cell biotechnology ... the stem cell medicine and pharmaceutical industries have easier access to stem cell counting, ... July 5 of this year, Independence Day weekend in the U.S., Asymmetrex is offering ...
Breaking Biology News(10 mins):
(Date:6/19/2020)... PETERSBURG, Russia (PRWEB) , ... June 18, 2020 , ... ... in 2018. Its goal is to join forces to radically prolong life and find ... significantly postpone the aging period. This project was supported by various scientists from all ...
(Date:6/11/2020)... ... June 09, 2020 , ... Reducing carbon emissions has been and will continue ... to stock market dips, ways to reduce CO2 is something we can’t avoid. ... of the biofuels being produced today are created from recycled cooking oil or crops. ...
(Date:5/30/2020)... ... May 29, 2020 , ... The Conference Forum is pleased ... dedicated to the unique role of the Chief Medical Officer in the biotech ... problem-solving, best practices and career development of CMOs and Heads of R&D from ...
(Date:5/21/2020)... ... 2020 , ... Threats to intellectual property, political pressure to ... conventional wisdom that says the coronavirus pandemic will generally benefit biopharmaceutical companies, a ... pandemic commercially weaker, dealing with delays in new product launches and with fewer ...
Breaking Biology Technology:
Cached News: