HOME >> BIOLOGY >> NEWS
Prenatal genistein in soy reduces obesity in offspring

DURHAM, N.C. -- A single nutrient found in soy products elicits changes in gene behavior that permanently reduce an embryo's risk of becoming obese later in life, according to an animal study at Duke University Medical Center.

The findings, yet to be confirmed in humans, could explain why Asians have lower rates of obesity and cancer, said the Duke researchers. Asians consume large amounts of soy, which has been linked to lower rates of breast, endometrial and prostate cancer, among other health benefits.

In the Duke study, pregnant Agouti mice that ate a diet rich in genistein, an active ingredient in soy, gave birth to pups that stayed slimmer as adults. Mice that did not receive genistein in utero were much heavier as adults double the weight of their genistein-fed counterparts. Prenatal genistein also shifted the offspring's coat color from yellow to brown, demonstrating that a single nutrient can have a widespread systemic impact, said the researchers.

Genistein's effect occurred early in pregnancy, the equivalent of eight gestational days in humans. The Duke scientists said their results lend support to the "developmental origins of adult disease" hypothesis, in which an individual's long-term health is influenced by prenatal factors.

Results of the study, funded by the National Institute of Environmental Health Sciences and the National Cancer Institute, are published in the April 1, 2006, issue of the journal Environmental Health Perspectives.

"We are increasingly finding that our parent's and even our grandparent's nutritional status and environmental exposures can regulate our future risk of disease," said Randy Jirtle, Ph.D., professor of radiation oncology and senior author of the study. "In other words, it may not only be the hamburgers and fries we are eating, but also what our parents consumed or encountered in the environment that predisposes us to various conditions."

Jirtle said a mechanism called DN
'"/>

Contact: Becky Levine
levin005@mc.duke.edu
919-684-4148
Duke University Medical Center
28-Mar-2006


Page: 1 2 3 4

Related biology news :

1. Prenatal stress keeps infants, toddlers up at night, study says
2. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
3. Prenatal toxicity linked to immune dysfunctions in later life
4. Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring
5. Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns
6. Prenatal cocaines lasting cellular effects
7. Prenatal alcohol exposure appears to increase an infants stress response
8. Prenatal vitamins may reduce risk of brain tumors in children
9. Prenatal health strongly influences future economic success
10. Prenatal nicotine exposure reduces breathing response of newborns...
11. Prenatal pesticide exposure and high blood pressure and a decreased ability to copy shapes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. ... awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of ... optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been ... Medical Neoasis™ active noise control device to attenuate typical noises in a simulated ... attenuated the alarm sounds from patient monitors, ventilators and other bedside devices that ...
(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the first in ... on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor ... live on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... PORTLAND, Ore. (PRWEB) , ... August 13, 2020 , ... ... announced the creation of its Scientific Advisory Board (SAB) to research the medical ... medical cannabis can be enhanced when combined with terpenes. The board is focused on ...
(Date:8/12/2020)... HOUSTON (PRWEB) , ... August ... ... a biopharmaceutical cold chain validation engineering firm, is making available for ... driving the need to incorporate concurrent transport simulation testing into today’s biologics ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... announced Jim Corrigan, President and CEO has been named one of the 100 ... of industry sectors, PharmaVoice 100 honorees are selected based on how they have ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader ... tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a time ... track capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical ...
Breaking Biology Technology:
Cached News: