HOME >> BIOLOGY >> NEWS
Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring

WASHINGTON -- At least 11 percent of American women smoke during pregnancy. The negative effects of nicotine exposure to their fetuses and newborns are significant. A 2004 report by the Surgeon General, for example, found that women who smoked during pregnancy had children who were at a three times higher risk for SIDS than were the offspring of non-smokers. Now, a new study using laboratory rats, provides strong evidence that the effects of maternal smoking during the prenatal period of life can lead to cardiac vascular dysfunction beyond the formative years -- and into adulthood.

The finding is part of a new study entitled Effect of Prenatal Nicotine Exposure on Coronary Flow in Adult Offspring: A Gender Dichotomy. It was conducted by Daliao Xiao, Jennifer Lawrence, Shumei Yang, and Lubo Zhang, all of the Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, and the Department of Chemistry and Biochemistry, California State University, San Bernardino, CA Dr. Zhang will lead a discussion of the findings at the 120th annual meeting of the American Physiological Society (APS; www.the-APS.org), being held as part of the Experimental Biology (EB 07) meeting. More than 12,000 scientists and researchers are attending the conference, being held April 28-May 2, 2007 at the Washington, DC Convention Center.

Summary of Methodology

Nicotine (2.1 mg/d) was administered via osmotic minipumps placed under the skin throughout gestation and up to ten days after delivery. Hearts were isolated from three month old male and female offspring, and subjected to 25-minutes of mechanical obstruction of blood flow ischemia followed by 60-minutes of myocardial impairment caused by opening of the blockage. Pulmonary artery discharge was collected as an index of coronary flow (ml/min/g heart wet weight).

Summary of Results

The researchers found:

  • that n
    '"/>


Contact: Donna Krupa
DKrupa@the-APS.org
301-634-7209
American Physiological Society
1-May-2007


Page: 1 2

Related biology news :

1. Prenatal stress keeps infants, toddlers up at night, study says
2. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
3. Prenatal toxicity linked to immune dysfunctions in later life
4. Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns
5. Prenatal cocaines lasting cellular effects
6. Prenatal alcohol exposure appears to increase an infants stress response
7. Prenatal vitamins may reduce risk of brain tumors in children
8. Prenatal health strongly influences future economic success
9. Prenatal nicotine exposure reduces breathing response of newborns...
10. Prenatal genistein in soy reduces obesity in offspring
11. Prenatal pesticide exposure and high blood pressure and a decreased ability to copy shapes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... the first robotic gym for the rehabilitation and functional motor sense evaluation ... Genoa, Italy . The first 30 robots will be available from ... . The technology was developed and patented at the IIT laboratories ... Technology thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:7/16/2017)... (PRWEB) , ... July 16, 2017 , ... ... equipment and analytical instruments announced the launch of its new line of Extreme ... ideal for applications that require CO2 and humidity for optimal cell growth such ...
(Date:7/14/2017)... ... 14, 2017 , ... Sonic Manufacturing Technologies is proud to ... a solar system on its roof top. “We will be independent of the ... Raab stated. The company’s proud history of social responsibility and participation in the ...
(Date:7/14/2017)... ... July 13, 2017 , ... LGC Maine Standards ... US FDA 510 (k) clearance for use on Siemens Sysmex® CS-2500 System analyzers. ... D-Dimer kit, prepared using the CLSI EP06-A “equal delta” sample preparation, offers five ...
(Date:7/13/2017)... ... July 13, 2017 , ... Thousands of pilots from across the country will ... Championships (Nats). Pilots come to Muncie to compete in various categories of model flying ... that participate in world championships. , RC Pylon (July 14-21): One of the most ...
Breaking Biology Technology:
Cached News: