HOME >> BIOLOGY >> NEWS
Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring

WASHINGTON -- At least 11 percent of American women smoke during pregnancy. The negative effects of nicotine exposure to their fetuses and newborns are significant. A 2004 report by the Surgeon General, for example, found that women who smoked during pregnancy had children who were at a three times higher risk for SIDS than were the offspring of non-smokers. Now, a new study using laboratory rats, provides strong evidence that the effects of maternal smoking during the prenatal period of life can lead to cardiac vascular dysfunction beyond the formative years -- and into adulthood.

The finding is part of a new study entitled Effect of Prenatal Nicotine Exposure on Coronary Flow in Adult Offspring: A Gender Dichotomy. It was conducted by Daliao Xiao, Jennifer Lawrence, Shumei Yang, and Lubo Zhang, all of the Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, and the Department of Chemistry and Biochemistry, California State University, San Bernardino, CA Dr. Zhang will lead a discussion of the findings at the 120th annual meeting of the American Physiological Society (APS; www.the-APS.org), being held as part of the Experimental Biology (EB 07) meeting. More than 12,000 scientists and researchers are attending the conference, being held April 28-May 2, 2007 at the Washington, DC Convention Center.

Summary of Methodology

Nicotine (2.1 mg/d) was administered via osmotic minipumps placed under the skin throughout gestation and up to ten days after delivery. Hearts were isolated from three month old male and female offspring, and subjected to 25-minutes of mechanical obstruction of blood flow ischemia followed by 60-minutes of myocardial impairment caused by opening of the blockage. Pulmonary artery discharge was collected as an index of coronary flow (ml/min/g heart wet weight).

Summary of Results

The researchers found:

  • that n
    '"/>


Contact: Donna Krupa
DKrupa@the-APS.org
301-634-7209
American Physiological Society
1-May-2007


Page: 1 2

Related biology news :

1. Prenatal stress keeps infants, toddlers up at night, study says
2. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
3. Prenatal toxicity linked to immune dysfunctions in later life
4. Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns
5. Prenatal cocaines lasting cellular effects
6. Prenatal alcohol exposure appears to increase an infants stress response
7. Prenatal vitamins may reduce risk of brain tumors in children
8. Prenatal health strongly influences future economic success
9. Prenatal nicotine exposure reduces breathing response of newborns...
10. Prenatal genistein in soy reduces obesity in offspring
11. Prenatal pesticide exposure and high blood pressure and a decreased ability to copy shapes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population ... challenge of how to continue to feed a growing nation. At the same time, ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography (sEMG) ... tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase III ...
(Date:10/7/2017)... Oct. 6, 2017  The 2017 Nobel Prize ... scientists, Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to ... structural biology community. The winners worked with systems ... routinely produce highly resolved, three-dimensional images of protein ...
Breaking Biology Technology:
Cached News: