Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring

WASHINGTON -- At least 11 percent of American women smoke during pregnancy. The negative effects of nicotine exposure to their fetuses and newborns are significant. A 2004 report by the Surgeon General, for example, found that women who smoked during pregnancy had children who were at a three times higher risk for SIDS than were the offspring of non-smokers. Now, a new study using laboratory rats, provides strong evidence that the effects of maternal smoking during the prenatal period of life can lead to cardiac vascular dysfunction beyond the formative years -- and into adulthood.

The finding is part of a new study entitled Effect of Prenatal Nicotine Exposure on Coronary Flow in Adult Offspring: A Gender Dichotomy. It was conducted by Daliao Xiao, Jennifer Lawrence, Shumei Yang, and Lubo Zhang, all of the Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, and the Department of Chemistry and Biochemistry, California State University, San Bernardino, CA Dr. Zhang will lead a discussion of the findings at the 120th annual meeting of the American Physiological Society (APS; www.the-APS.org), being held as part of the Experimental Biology (EB 07) meeting. More than 12,000 scientists and researchers are attending the conference, being held April 28-May 2, 2007 at the Washington, DC Convention Center.

Summary of Methodology

Nicotine (2.1 mg/d) was administered via osmotic minipumps placed under the skin throughout gestation and up to ten days after delivery. Hearts were isolated from three month old male and female offspring, and subjected to 25-minutes of mechanical obstruction of blood flow ischemia followed by 60-minutes of myocardial impairment caused by opening of the blockage. Pulmonary artery discharge was collected as an index of coronary flow (ml/min/g heart wet weight).

Summary of Results

The researchers found:

  • that n

Contact: Donna Krupa
American Physiological Society

Page: 1 2

Related biology news :

1. Prenatal stress keeps infants, toddlers up at night, study says
2. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
3. Prenatal toxicity linked to immune dysfunctions in later life
4. Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns
5. Prenatal cocaines lasting cellular effects
6. Prenatal alcohol exposure appears to increase an infants stress response
7. Prenatal vitamins may reduce risk of brain tumors in children
8. Prenatal health strongly influences future economic success
9. Prenatal nicotine exposure reduces breathing response of newborns...
10. Prenatal genistein in soy reduces obesity in offspring
11. Prenatal pesticide exposure and high blood pressure and a decreased ability to copy shapes

Post Your Comments:

(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita ... miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject of ... now. , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology:
Cached News: