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Prenatal vitamins may reduce risk of brain tumors in children

Women who take multivitamins early in pregnancy may reduce the risk that their child will develop some types of brain tumors.

Public health agencies already urge pregnant women to take multivitamins that contain folic acid early in pregnancy to reduce their fetus's risk of developing a neural tube defect such as spina bifida. "This current study suggests another possible protective effect for the vitamins," said study leader Greta R. Bunin, Ph.D., of The Children's Hospital of Philadelphia. She added, "Children whose mothers took multivitamins close to the time of conception seemed less likely to suffer medulloblastoma and primitive neuroectodermal tumors of the brain."

While childhood brain tumors are, fortunately, relatively rare, medulloblastoma is the second most common brain tumor in children. Occurring in one in 20,000 children under age six, it appears in the cerebellum, the lower portion of the brain, and the area of the brain that coordinates movement. Primitive neuroectodermal tumors of the brain (PNET) are similar to medulloblastoma but occur in other parts of the central nervous system.

Dr. Bunin led a study comparing 315 children diagnosed with those tumors before age six to 315 randomly chosen healthy children. The children with cancer, all of whom were diagnosed between 1991 and 1997, were registered in the Children's Oncology Group, a multicenter collaborative organization of pediatric cancer programs in the U.S. and Canada.

The researchers questioned the mothers in a telephone survey. The study appears in the September issue of Cancer Epidemiology Biomarkers and Prevention.

The protective effect of the multivitamins taken early in pregnancy was weakly significant, but because it was similar to previous, more statistically significant findings by Dr. Bunin's team in 1993, the authors conclude the apparent benefit is unlikely to have occurred by chance.

The researchers found that taking
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Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
20-Sep-2006


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