HOME >> BIOLOGY >> NEWS
Preterm birth risk quickly and accurately detected with proteomic profiling

By profiling specific proteins in amniotic fluid for inflammation, researchers at Yale School of Medicine can quickly and accurately detect potentially dangerous infections in pregnant women, and also predict the possibility of premature birth.

The work will be presented at the 26th Annual Society for Maternal-Fetal Medicine (SMFM) meeting on February 2 by Catalin S. Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology & Reproductive Sciences. Buhimschi and his team will receive a March of Dimes Award for Best Research in Prematurity.

"This is one of the first tests of a proteomic profile in a prospective-blind fashion," said Buhimschi. "One of the key advances in this research is that the test was done using fresh samples of amniotic fluid and not using banked amniotic fluid. This is a multidisciplinary approach that combines the basic science with clinical neonatology."

Mass Restricted (MR) score is a specific proteomic profile used in the study. Presence of the biomarkers indicating inflammation in amniotic fluid can be established in 20 to 30 minutes. This test is much faster than the current method of testing microbiological cultures. If no biomarkers are present, then the pregnancy is uncomplicated.

Buhimschi and his team studied 164 fresh samples of amniotic fluid from 131 patients recruited consecutively with symptoms of premature labor. Proteins in a small sample of amniotic fluid were tested to find a link between the amniotic fluid glucose value, white blood cell count and the outcome of the fetus. An MR sore of three or four is highly predictive of adverse pregnancy outcome.

"We can now detect infections at a much more incipient stage with this proteomic profile," said Buhimschi. "The presence of two biomarkers for inflammation indicates the median time for delivery is four days. If all the biomarkers for inflammation are present, delivery time occurs within hours. Studies to test tr
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
2-Feb-2006


Page: 1 2

Related biology news :

1. Preterm infants with RDS -- surfactant replacement therapies improves neonatal survival
2. Pregnancy news -- Preterm delivery risk reduced by high-dose progesterone treatment
3. Risk of common vaginal infection linked to preterm birth appears higher for blacks
4. Universes stringy birth revealed by young Czech scientist in EURYI winning project
5. Progesterone injections do not prevent preterm birth in twin pregnancies
6. Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
7. Pre-implantation genetic screening reduces both ongoing pregnancy and live birth rates in over 35s
8. Fine particulate matter from traffic may influence birth weight
9. Penn researchers report that gene therapy awakens the brain despite blindness from birth
10. Noninvasive screening in early pregnancy reduces Downs births by 50 percent
11. Rapid syphilis testing in Haiti will prevent congenital disease and stillbirths

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... 05, 2019 , ... Pelican BioThermal , the global ... service center in Mexico City, Mexico. Mexico is the second largest pharmaceutical market ... $1.75 billion in pharmaceutical exports since 2015. The Mexico City network station will ...
(Date:6/4/2019)... (PRWEB) , ... June 04, 2019 , ... ... the search for salient features of seizure risk signals, usually based on variations ... EEG interpretation remains the only acceptable diagnostic methodology due to the complexity and ...
(Date:5/31/2019)... ... May 30, 2019 , ... Researchers ... Mayo Clinic, have documented significant differences in the prevalence of hereditary genetic mutations, ... compared to non-Hispanic White women. Results will be presented at the 2019 American ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... 29, 2019 , ... For many years, the primary forms of cancer treatment ... therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T ... cell receptors known as “CARs”. The CAR enables the final product to produce chemicals ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... first to demonstrate an efficient delivery system for the sustained release of human ... platelet-rich plasma-based gel system was able to deliver CM into the injured kidney, ...
(Date:5/15/2019)... ... 16, 2019 , ... Emulsifiers are the magic bullet when ... rely on these ingredients to create stable quality food that can withstand shelf-life ... triggers food formulators to seek out alternatives for starches, gums and chemical emulsifiers. ...
(Date:5/7/2019)... Columbia (PRWEB) , ... May 06, 2019 , ... ... a go-to resource for the growing number of repositories being asked to store ... are grateful to the team of contributors who are world leaders, who have ...
Breaking Biology Technology:
Cached News: