HOME >> BIOLOGY >> NEWS
Preventing bacterial biofilms could help fight TB

HHMI researchers have identified a gene that enables mycobacteria--the cause of tuberculosis and leprosy--to form biofilms. Bacterial biofilms help mycobacteria resist treatment. But researchers found that when mycobacteria closely related to the TB and leprosy pathogens lack one key protein, mature biofilms fail to form. Interrupting the gene that produces this protein, known as GroEL1, could help treat or prevent these dread diseases

To decipher the protein's role in biofilm construction, Graham F. Hatfull, a Howard Hughes Medical Institute (HHMI) professor at the University of Pittsburgh, collaborated with HHMI investigator William R. Jacobs, Jr., at Albert Einstein College of Medicine. They discovered that GroEL1 oversees the production of a particular set of fatty acids called mycolic acids, which are necessary for biofilm growth.

Hatfull is one of 20 scientists nationwide who received $1 million each from HHMI to help bring the excitement of research into the science classroom. He works with undergraduates and Pittsburgh area high school students to identify bacteriophages, common viruses that infect bacteria. A bacteriophage infecting Mycobacterium smegmatis, a non-pathogenic cousin of Mycobacterium tuberculosis, helped launch the study that Hatfull and Jacobs report in the December 2, 2005 issue of the journal Cell.

"We've defined one of the first genes and mechanisms through which mycobacteria form biofilms," said Hatfull. "Understanding biofilms is important because bacteria in biofilms are tolerant to most antibiotics, and this tolerance is a major problem in controlling TB infections," he explained.

TB infects one in three people worldwide and kills thousands each day in third-world countries. Infections can also persist undetected for a lifetime. "Biofilms could play an important role in how TB itself can hunker down and protect itself from drugs and immune effector killing mechanisms. Perhaps TB hangs out in a biofilm
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
1-Dec-2005


Page: 1 2 3

Related biology news :

1. Preventing and treating lung cancer -- ESMO explores collaboration to fight cancer on all fronts
2. Preventing cancer without killing cells
3. Preventing obesity in children -- research highlights physical activity levels
4. Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
5. Preventing ventilation induced lung injury depends on giving the right number of sighs
6. Preventing fetal exposure to popular acne drug
7. Preventing a pandemic: Study suggests strategies for containing a flu outbreak
8. Size matters: Preventing large mammal extinction
9. Preventing muscle atrophy
10. Undesirable expatriates: Preventing the spread of invasive animals
11. Preventing SCD1 expression prevents obesity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
Breaking Biology Technology:
Cached News: