HOME >> BIOLOGY >> NEWS
Preventing ventilation induced lung injury depends on giving the right number of 'sighs'

Bethesda, MD. (July 25, 2006) Ventilation therapy burst into the public consciousness more than 60 years ago with the "iron lung" and the polio epidemic. Mechanical ventilation has come a long way since then and is used today with patients who cannot breathe on their own because of trauma, lung injuries and chronic lung disease.

But ventilation demands a delicate balance between over inflating and under inflating the lungs, either of which can lead to further injury. Researchers have found that pumping too much air overdistends the lung, leading to ventilator-induced lung injury (VILI).

Doctors currently use small amounts of air (low tidal volume) to protect against VILI. But low tidal volumes can lead to progressive closure of the lungs' air cells, called alveoli, reducing the lung's ability to exchange gases. One way to reverse closure of the alveoli is to periodically give a more robust puff of air, known as deep inflation.

A new study in the online edition of the American Journal of Physiology-Lung Cellular and Molecular Physiology shows that low tidal volume combined with periodic deep inflation provides the best balance between keeping the lung open and preventing VILI in mice. And, using mice, these researchers have shown for the first time that although deep inflation is necessary, it can be overdone.

"There is still a lot of controversy and uncertainty about how best to ventilate the lung," said the study's senior author, Jason HT Bates of the University of Vermont. "One controversy is whether deep inflations, the "sighs" that each of us takes periodically, should ever be given, and if so, how frequently."

Researchers find optimal range

"This study demonstrates that an optimal frequency range of deep inflation delivery exists, at which point the potentially injurious effects of overdistention are outweighed by the protective benefits of maintaining a predominantly open lung," wrote Gilma
'"/>

Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
25-Jul-2006


Page: 1 2 3 4

Related biology news :

1. Preventing and treating lung cancer -- ESMO explores collaboration to fight cancer on all fronts
2. Preventing cancer without killing cells
3. Preventing obesity in children -- research highlights physical activity levels
4. Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
5. Preventing bacterial biofilms could help fight TB
6. Preventing fetal exposure to popular acne drug
7. Preventing a pandemic: Study suggests strategies for containing a flu outbreak
8. Size matters: Preventing large mammal extinction
9. Preventing muscle atrophy
10. Undesirable expatriates: Preventing the spread of invasive animals
11. Preventing SCD1 expression prevents obesity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2017)... LONDON , February 21, 2017 ... um 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr ... es einige Hindernisse zu überwinden gilt, um diese Prognose ... ... unter anderem die Mobilisierung der finanziellen Mittel für die ...
(Date:2/14/2017)... N.C. , Feb. 14, 2017  Wake Forest ... M.D., as its new chief executive officer (CEO). Freischlag ... CEO John D. McConnell , M.D., who last ... position at the Medical Center, after leading it since ... the full scope of Wake Forest Baptist,s academic health ...
(Date:2/13/2017)... Former 9/11 Commission border counsel and Special ... Kephart of Identity Strategy Partners, LLP, today releases ... "Executive Order: Protecting the Nation From Foreign Terrorist Entry ... "As President Trump,s ,Travel Ban, Executive Order gains more ... the travel ban, it is important that our national ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... 22, 2017  RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced ... will present at the 5th Annual Cancer BioPartnering ... platform to present to and meet with thought ... biotech companies as well as institutional investors. This ...
(Date:3/20/2017)... ... , ... SSCI and Whitehouse Laboratories, divisions of Albany Molecular Research, Inc, are ... the Parenteral Drug Association (PDA), the New York Interphex Show will open on March ... more than 625 exhibitors, the educational and networking opportunities are extremely valuable. INTERPHEX is ...
(Date:3/20/2017)... ... March 20, 2017 , ... HOLLOWAY AMERICA, a leading manufacturer ... will debut a brand new pressure vessel, the intelliVessel™, at INTERPHEX 2017 at ... touch screen panel and features other revolutionary operations that promote safer, more efficient ...
(Date:3/20/2017)... Linda, CA (PRWEB) , ... March 20, 2017 ... ... and require expensive and laborious sample preparation methods in order to reduce the ... often underappreciated outside of the area of elemental analysis. , This presentation ...
Breaking Biology Technology:
Cached News: