Next step
"Our findings have obvious implications for the recruitment of the injured human lung during low tidal ventilation," the authors wrote. "However, extrapolating our results to the clinical situation must be done guardedly. In the present study we employed uninjured mice, whereas it is known that the injured lung is more prone to atelectasis (collapse) than a normal lung."
Bates' team hopes to move to a human trial in the near future, now that they have established that deep inflation is beneficial and can be delivered with an optimal frequency.
Source
"Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injury," by Gilman B. Allen, Benjamin T. Suratt, Lisa Rinaldi and Joseph M. Petty and Jason HT Bates, Vermont Lung Center, Department of Medicine, University of Vermont, Burlington. Allen, Suratt and Bates are also affiliated with the Fletcher Allen Health Care, Burlington. The study appears in the online edition of American Journal of Physiology Lung Cellular and Molecular Physiology published by The American Physiological Society.
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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
25-Jul-2006