Primitive yeast yields secrets of human cholesterol and drug metabolism

sterol is essential for cell survival.

To show that Dap1 directly works with P450s and not through some other biochemical steps, Espenshades team tested the ability of human Dap1 protein to bind to four of the 57 known human P450 enzymes, essentially challenging Dap1 to bind to P450s that perform totally different functions in different cells as a way to see how far-reaching its control might be.

Dap1 locked on to all four P450s, including one required for clearing half of all known drugs from the body, another involved in making bile and one required for making natural steroid hormones in the adrenal glands.

Collectively, our experiments suggest that Dap1 acts as a common regulator of cytochrome P450s in mammals, says Espenshade.

Because Dap1 affects one particular P450 responsible for drug metabolism, Espenshade suspects that genetic variations in the genetic blueprint coding for Dap1 may provide clues to how and why different people react differently to certain drugs.

Understanding the molecular underpinnings of so-called pharmacogenetic variation will have a big impact on the future of medicine, he says.


Contact: Audrey Huang
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Tiny tweezers and yeast help St. Jude show how cancer drug works
2. Hives ferment a yeasty brew, attract beetle pest
3. Vitamin extends life in yeast, Dartmouth Medical School researchers find
4. Protein structures for the entire yeast proteome
5. MIT: Engineered yeast speeds ethanol production
6. Engineered yeast speeds ethanol production
7. From a lowly yeast, researchers divine a clue to human disease
8. Potassium limitation, ammonium toxicity and amino acid excretion in yeast
9. Dartmouth and GlycoFi report full humanization of therapeutic proteins from yeast
10. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
11. First comprehensive literature-derived database of yeast interactions

Post Your Comments:
(Date:9/30/2015)... Calif. , Sept. 30, 2015  With nearly ... the number of new SCIs estimated to reach 12,500 ... Southern California Resource Services for Independent Living ... ILCs in California opening doors ... range of programs and services, notably assistive technology services ...
(Date:9/29/2015)... SUNNYVALE, Calif. , Sept. 29, 2015 ... technology improves employee productivity while also saving energy ... features such as Low Power Active Mode and embedded ... workplace transformation Fujitsu today shows that ... of new and refreshed models to its enterprise desktop ...
(Date:9/28/2015)... Sept. 28, 2015  The monitoring of vital ... body temperature, is an essential component of patient ... of deterioration in a patient,s condition. However, in ... are typically taken during routine observation rounds only ... patient deteriorates between these observation rounds, the warning ...
Breaking Biology News(10 mins):
(Date:10/8/2015)... ... 08, 2015 , ... Cystic fibrosis (CF) is a genetic ... and results in dysfunction of the lungs and the gastrointestinal (GI) tract. In ... is very difficult to clear, blocks the airways and the glands, and creates ...
(Date:10/7/2015)... ... 07, 2015 , ... Neil Riordan, PhD to Discuss Medicinal Effects of Mesenchymal ... Mar-a-Lago from 3:50 pm to 4:30 pm. , Dr. Riordan is one of the ... He is the Co-Founder and Chief Science Officer of the Riordan-McKenna Institute ...
(Date:10/7/2015)... 2015  ContraVir Pharmaceuticals, Inc. (Nasdaq: CTRV ) ... the development and commercialization of targeted antiviral therapies, today ... 5,000,000 shares of its common stock and warrants to ... stock at a fixed combined price to the public ... will be issued separately.  The warrants will be exercisable ...
(Date:10/7/2015)... Pa. , Oct. 7, 2015   VWR ... independent provider of laboratory products, services and solutions, ... Inc. (PTI), a specialty solvent company that performs ... This acquisition will enhance VWR,s growing laboratory and ... laboratory and biopharmaceutical manufacturing customers. Manuel ...
Breaking Biology Technology:
Cached News: