HOME >> BIOLOGY >> NEWS
Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study

A pro-inflammatory protein activated by bacteria in the colon plays a key role in the development of experimental colitis in mice a mouse-version of human Crohn's disease according to research by scientists at the University of California, San Diego (UCSD) School of Medicine.

The study, published in the February 4, 2005 issue of the journal Science, identified interleukin-1Beta (IL-1) as a major cause of severe inflammation in the mouse model of Crohn's disease, which is a painful, chronic and little-understood inflammatory bowel disease (IBD) in humans, affecting more than 500,000 Americans. These individuals are considered at high risk for colon cancer.

The identification of IL-1 offers a potential target for drug development, said the study's senior author, Michael Karin, Ph.D., UCSD professor of pharmacology and an American Cancer Society Research Professor. Although there is currently an IL-1 inhibitor on the market for other, non-Crohn's chronic inflammatory conditions such as rheumatoid arthritis, this drug is not a very potent IL-1 inhibitor.

"Now that we've identified IL-1 as an important target for Crohn's disease therapy, we hope that a better, more effective IL-1 inhibiting drug can be developed for testing its efficacy in these patients," Karin said.

Crohn's disease is thought to involve an interaction between a genetic defect and environmental factors such as bacterial infections that trigger the disorder. Recently, scientists identified mutations in a gene called NOD2 as leading to 50 percent of Crohn's cases in patients of Northern European descent, but they haven't known just how NOD2 causes the severe inflammation associated with the disorder. An intracellular sensor for bacterial infection, normal NOD2 activates a protein called nuclear factor-kappaB (NF-kB), which is involved in the immune system's rapid response to bacterial infection. It has been observed that many of the drugs currently used to help Crohn
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
3-Feb-2005


Page: 1 2

Related biology news :

1. Pro-inflammatory enzyme linked to diabetes; Immune systems macrophages may be key to treatment
2. Penn researchers discover how key protein stops inflammation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Discovery of new protein could provide new understanding of male fertility
6. Unlocking proteins from their cellular shell
7. Altering a protein makes mice less fearful
8. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
9. MicroRNA works with Ago2 protein to regulate blood cell development
10. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
11. Call for EU to launch major project to map out all our proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/5/2019)... TORONTO (PRWEB) , ... January 04, 2019 , ... ... Chief Architect – two experts in Healthcare & Life Sciences from MarkLogic – ... EST (4pm GMT). , This presentation outlines the challenges of using real world ...
(Date:1/4/2019)... ... January 03, 2019 , ... Over the last few years, ... discovery research workflows with biology ranging from single cell-type spheroids to highly complex ... studies, they create several challenges that need to be overcome in order to ...
(Date:12/27/2018)... ... December 27, 2018 , ... AxioMed completed its ... Boston facility, and is now raising growth capital to ramp up demand for ... against inferior ball and socket discs. The capital raise is targeted to qualified ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... Leading authority ... an all-new, how-to guide with his “The Referral Playbook: How to Increase Sales ... of the book proceeds will go to the Alzheimer’s Foundation of America (AFA). ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic software ... – has been used to convict a Wyoming man of third-degree sexual assault, a ... used STRmix™ to test for DNA on the couch cushions on which the sexual ...
(Date:11/29/2018)... ... November 29, 2018 , ... RAGS, today announced the closing ... Seed Fund, with participation from existing investor and board member Jeremy Andrus, CEO of ... Cotopaxi. The additional funding will enable the company to accelerate its growth and expand ...
(Date:11/27/2018)... , ... November 27, 2018 , ... New patients in ... Dr. Dan Myers’ practice for treatment, with or without a referral. Dr. Myers has ... tools, including porcelain veneers, dental implants, bridges and custom crowns. , As a ...
Breaking Biology Technology:
Cached News: