HOME >> BIOLOGY >> NEWS
Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study

A pro-inflammatory protein activated by bacteria in the colon plays a key role in the development of experimental colitis in mice a mouse-version of human Crohn's disease according to research by scientists at the University of California, San Diego (UCSD) School of Medicine.

The study, published in the February 4, 2005 issue of the journal Science, identified interleukin-1Beta (IL-1) as a major cause of severe inflammation in the mouse model of Crohn's disease, which is a painful, chronic and little-understood inflammatory bowel disease (IBD) in humans, affecting more than 500,000 Americans. These individuals are considered at high risk for colon cancer.

The identification of IL-1 offers a potential target for drug development, said the study's senior author, Michael Karin, Ph.D., UCSD professor of pharmacology and an American Cancer Society Research Professor. Although there is currently an IL-1 inhibitor on the market for other, non-Crohn's chronic inflammatory conditions such as rheumatoid arthritis, this drug is not a very potent IL-1 inhibitor.

"Now that we've identified IL-1 as an important target for Crohn's disease therapy, we hope that a better, more effective IL-1 inhibiting drug can be developed for testing its efficacy in these patients," Karin said.

Crohn's disease is thought to involve an interaction between a genetic defect and environmental factors such as bacterial infections that trigger the disorder. Recently, scientists identified mutations in a gene called NOD2 as leading to 50 percent of Crohn's cases in patients of Northern European descent, but they haven't known just how NOD2 causes the severe inflammation associated with the disorder. An intracellular sensor for bacterial infection, normal NOD2 activates a protein called nuclear factor-kappaB (NF-kB), which is involved in the immune system's rapid response to bacterial infection. It has been observed that many of the drugs currently used to help Crohn
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
3-Feb-2005


Page: 1 2

Related biology news :

1. Pro-inflammatory enzyme linked to diabetes; Immune systems macrophages may be key to treatment
2. Penn researchers discover how key protein stops inflammation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Discovery of new protein could provide new understanding of male fertility
6. Unlocking proteins from their cellular shell
7. Altering a protein makes mice less fearful
8. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
9. MicroRNA works with Ago2 protein to regulate blood cell development
10. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
11. Call for EU to launch major project to map out all our proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... ... of Common Lisp (CL) development tools, and market leader for Semantic Graph ... performance enhancements now available within the most effective system for developing and deploying ...
(Date:4/25/2017)... ... April 25, 2017 , ... Dr. Robert G. ... , proudly announced today that acclaimed physiatrist Matthew Terzella, MD, has joined the ... 2017. , Dr. Terzella completed his residency in Physical Medicine and Rehabilitation at ...
(Date:4/24/2017)... ... April 24, 2017 , ... It is well ... milieu; however, the broad application of this cellular target engagement concept to drug ... readouts. Cell-based thermal stabilization assays are valuable methods for particular applications, but they ...
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design ... is pleased to introduce it to top lab design architects from around the country ... and VP of Industrial Design and Engineering Greg Casey will be at the show, ...
Breaking Biology Technology:
Cached News: