HOME >> BIOLOGY >> NEWS
Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study

A pro-inflammatory protein activated by bacteria in the colon plays a key role in the development of experimental colitis in mice a mouse-version of human Crohn's disease according to research by scientists at the University of California, San Diego (UCSD) School of Medicine.

The study, published in the February 4, 2005 issue of the journal Science, identified interleukin-1Beta (IL-1) as a major cause of severe inflammation in the mouse model of Crohn's disease, which is a painful, chronic and little-understood inflammatory bowel disease (IBD) in humans, affecting more than 500,000 Americans. These individuals are considered at high risk for colon cancer.

The identification of IL-1 offers a potential target for drug development, said the study's senior author, Michael Karin, Ph.D., UCSD professor of pharmacology and an American Cancer Society Research Professor. Although there is currently an IL-1 inhibitor on the market for other, non-Crohn's chronic inflammatory conditions such as rheumatoid arthritis, this drug is not a very potent IL-1 inhibitor.

"Now that we've identified IL-1 as an important target for Crohn's disease therapy, we hope that a better, more effective IL-1 inhibiting drug can be developed for testing its efficacy in these patients," Karin said.

Crohn's disease is thought to involve an interaction between a genetic defect and environmental factors such as bacterial infections that trigger the disorder. Recently, scientists identified mutations in a gene called NOD2 as leading to 50 percent of Crohn's cases in patients of Northern European descent, but they haven't known just how NOD2 causes the severe inflammation associated with the disorder. An intracellular sensor for bacterial infection, normal NOD2 activates a protein called nuclear factor-kappaB (NF-kB), which is involved in the immune system's rapid response to bacterial infection. It has been observed that many of the drugs currently used to help Crohn
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
3-Feb-2005


Page: 1 2

Related biology news :

1. Pro-inflammatory enzyme linked to diabetes; Immune systems macrophages may be key to treatment
2. Penn researchers discover how key protein stops inflammation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
5. Discovery of new protein could provide new understanding of male fertility
6. Unlocking proteins from their cellular shell
7. Altering a protein makes mice less fearful
8. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
9. MicroRNA works with Ago2 protein to regulate blood cell development
10. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
11. Call for EU to launch major project to map out all our proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/31/2017)... , Jan. 31, 2017  Spero Therapeutics, LLC, ... for the treatment of bacterial infections, today announced ... antibacterial candidates from Pro Bono Bio Ltd (PBB) ... of multi-drug resistant forms of Gram-negative bacteria.   The ... Infectives Ltd, a PBB group company. ...
(Date:1/25/2017)... Jan. 25, 2017 The Elements of Enterprise ... lifecycle is comprised of a comprehensive set of ... of maintaining digital identities and providing a secured ... There are significant number of programs opted by ... time by optimizing processes and changing policies. However, ...
(Date:1/21/2017)... Research and Markets has announced the addition of the ... ... voice recognition biometrics market to grow at a CAGR of 19.36% ... present scenario and the growth prospects of the global voice recognition ... considers the revenue generated from the sales of voice recognition biometrics ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... , ... February 27, 2017 , ... The Catalyst ... a few in the Midwest offering premix services and private label organic services. , ... laying hens, according Jos Zamzow, chief operating officer of Dynamite Marketing, which owns the ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... be safely completed in an ambulatory surgery center (ASC) with satisfactory clinical and ... previous two-year TDR studies. , Jake Lubinski, president of AxioMed, commented on ...
(Date:2/24/2017)... Tenn. , Feb. 24, 2017 ... ("Provectus" or the "Company"), a clinical-stage oncology and ... regarding the deadline to participate in its previously ... units, consisting of shares of common stock and ... and holders of listed warrants. ...
(Date:2/24/2017)... 24, 2017  Driven by consumers, preference towards ... the fastest growing categories, finds the recently published ... Personal Care: Multi-regional Market Analysis and Opportunities ... firm Kline. "Biotechnology actives are derived ... more effective for skin and hair care applications," ...
Breaking Biology Technology:
Cached News: