HOME >> BIOLOGY >> NEWS
Probable trigger of kidney disease in diabetics identified

Researchers identified a protein that might trigger kidney disease in diabetic patients, a condition that affects one in three people with type 1 and one in ten people with type 2 diabetes. According to a new study led by researchers at Mount Sinai School of Medicine and Thomas Jefferson University published in the February issue of PLoS Medicine, the link between this particular protein and kidney disease points to yet another reason why it is critical that diabetics keep their blood glucose levels as close to normal as possible.

Kidney disease in diabetics, known as diabetic nephropathy is the leading cause of kidney failure worldwide. It is known that this disease occurs more frequently in people from South Asia and Africa, in men, in patients whose blood sugar is poorly controlled, and in those who either have high blood pressure or smoke. However, scientists do not fully understand how diabetes damages the kidneys.

Erwin Bttinger, MD, Professor of Medicine and Pharmacology and Biological Chemistry and Katalin Susztak, MD, PhD, Adjunct Assistant Professor of Medicine at Mount Sinai School of Medicine together with their collaborator, Kumar Sharma, MD, Professor of Medicine at Thomas Jefferson University studied samples of kidneys from humans and mice with and without diabetes and looked at the effects of high glucose concentrations on the cells in the kidneys. They found that in one part of the human kidney high glucose caused a change on the surface of cells which triggered the cells to increase production of a protein called CD36. The investigators also found that some substances that are often found in the blood of people with diabetes join to CD36 and that this process triggered the death of these kidney cells. Kidney cell death is one of the first steps to occur in diabetic nephropathy.

"Our findings provide insight into one of the crucial steps in the development of diabetic nephropathy," said Dr. Bottinger. "The role of CD36 may ex
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
22-Feb-2005


Page: 1 2

Related biology news :

1. p53 gene mutations and inflammation trigger skin cancer
2. University of Pittsburgh discovers genetic shut down trigger in healthy immune cells
3. Climate change could trigger boom and bust population cycles leading to extinction
4. Glucose triggers brain cell death in rats after hypoglycemic coma
5. Brain tissue reveals possible genetic trigger for schizophrenia
6. Chemical switch triggers critical cell activities
7. Dartmouth researchers find that arsenic triggers unique mechanism in rare leukemia
8. Failed experiment yields a biocontrol agent that doesnt trigger antibiotic resistance
9. Disabling a carbohydrate trigger reduces obesity and appetite
10. LIAI scientists identify immune system trigger for fighting Lyme disease
11. Growth factor triggers growth of new blood vessels in the heart

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: