HOME >> BIOLOGY >> NEWS
Probing the promise and perils of nanoparticles

a gain."

More recently, Leroueil studied other types of charged nanoparticles called polycationic polymers---already being used to deliver drugs and genes---to see if they behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl. Neutral polymers, however, did not damage membranes.

Both Leroueil's work and the earlier research used model membranes to probe the effects of nanoparticles. Now, the research group is exploring their interactions with living cells.

"Just because we see hole formation in the model system doesn't mean that it really happens in the cell," said Banaszak Holl. But early results of experiments with living cells suggest that the same types of nanoparticles that punch holes in model membranes also damage membranes in living cells and make the membranes more permeable. Hong is now trying to learn more about the biological mechanisms involved. The usual explanation for how polycationic polymers and similar nanoparticles get into cells involves a process called polycation-mediated endocytosis. But Hong's experiments suggest that nanoscale hole formation may be at least as important in allowing materials to travel through membranes.

The work that Banaszak Holl, Hong and Leroueil will discuss is one of several major research programs under way in the U-M Center for Biologic Nanotechnology---a multi-disciplinary group includes researchers from the Medical School, the College of Engineering, and the College of Literature, Science, and the Arts, and focuses on biomedical applications of nanomaterials. Collaborators on this work include James R. Baker, Jr., the Ruth Dow Doan Professor of Biologic Nanotechnology; Bradford Orr, professor of physics and director of the Applied Physics Program; research associate Jennifer Peters and research investigators Anna Bielinska and Istvan Majoros.


'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
15-Mar-2005


Page: 1 2

Related biology news :

1. Probing biologys dark matter
2. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
3. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
4. New proteomics research promises to revolutionize biomedical discovery
5. New research holds promise for protecting cancer patients against infertility
6. New approach to pulmonary hypertension shows promise
7. Modular leukemia drug shows promise in early testing
8. Hepatitis B drug can compromise HIV treatment
9. UCF nanoparticle offers promise for treating glaucoma
10. Identification of genetic risk factor for coeliac disease promises improved treatment
11. Canadian paper innovation holds promise for improved global health safety

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... ... ... NDA Partners Chairman Carl Peck, MD , announced today that Tara Maddala, ... drug and genomic diagnostic products for therapeutic indications in oncology, has joined the firm ... as Vice President of Biometrics at GRAIL, Inc., where she built and led a ...
(Date:4/18/2019)... ... April 18, 2019 , ... Medpricer, the ... launch of mSource® AI Contract Text Analysis. This contract mining tool uses machine ... contracts, truly optimizing purchased services spend at record speed. It can analyze more ...
(Date:4/16/2019)... ... 16, 2019 , ... The Healthcare Technology Report is pleased ... extensive process was run to evaluate the hundreds of CEOs that lead exemplary ... other related areas. We gathered data on each nominee’s professional background and assessed ...
Breaking Biology News(10 mins):
(Date:5/8/2019)... POWAY, Calif. (PRWEB) , ... May 07, 2019 , ... Standing at 16.2 hands, Atlas ... busy too, participating in a drill team and barrel racing, among other activities. When ... suspensory ligament. He went from being a busy horse to only being able to ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the ... ffERG/Photopic Negative Response vision test, a new full field electroretinography (ffERG) protocol ... that 6.3 million Americans will have glaucoma, with black Americans having the highest ...
(Date:5/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology ...
(Date:4/25/2019)... ... April 23, 2019 , ... Frank is an albino, deaf Great Dane. His owners ... him due to his health issues. Despite his hearing impairment, he was always an active ... two would play all day, every day. As the two grew, playtime became rougher and ...
Breaking Biology Technology:
Cached News: