HOME >> BIOLOGY >> NEWS
Probing the promise and perils of nanoparticles

a gain."

More recently, Leroueil studied other types of charged nanoparticles called polycationic polymers---already being used to deliver drugs and genes---to see if they behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl. Neutral polymers, however, did not damage membranes.

Both Leroueil's work and the earlier research used model membranes to probe the effects of nanoparticles. Now, the research group is exploring their interactions with living cells.

"Just because we see hole formation in the model system doesn't mean that it really happens in the cell," said Banaszak Holl. But early results of experiments with living cells suggest that the same types of nanoparticles that punch holes in model membranes also damage membranes in living cells and make the membranes more permeable. Hong is now trying to learn more about the biological mechanisms involved. The usual explanation for how polycationic polymers and similar nanoparticles get into cells involves a process called polycation-mediated endocytosis. But Hong's experiments suggest that nanoscale hole formation may be at least as important in allowing materials to travel through membranes.

The work that Banaszak Holl, Hong and Leroueil will discuss is one of several major research programs under way in the U-M Center for Biologic Nanotechnology---a multi-disciplinary group includes researchers from the Medical School, the College of Engineering, and the College of Literature, Science, and the Arts, and focuses on biomedical applications of nanomaterials. Collaborators on this work include James R. Baker, Jr., the Ruth Dow Doan Professor of Biologic Nanotechnology; Bradford Orr, professor of physics and director of the Applied Physics Program; research associate Jennifer Peters and research investigators Anna Bielinska and Istvan Majoros.


'"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
15-Mar-2005


Page: 1 2

Related biology news :

1. Probing biologys dark matter
2. Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
3. Radiation therapy combined with microsurgery shows promise for curing injured spinal cord
4. New proteomics research promises to revolutionize biomedical discovery
5. New research holds promise for protecting cancer patients against infertility
6. New approach to pulmonary hypertension shows promise
7. Modular leukemia drug shows promise in early testing
8. Hepatitis B drug can compromise HIV treatment
9. UCF nanoparticle offers promise for treating glaucoma
10. Identification of genetic risk factor for coeliac disease promises improved treatment
11. Canadian paper innovation holds promise for improved global health safety

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... FRANCISCO (PRWEB) , ... February 04, 2019 , ... ... of a new Explorer™ story which provides insights to help individuals understand how ... to decreased cardiovascular wellness. , After individuals eat foods that contain choline ...
(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, ... Testing Laboratories by A2LA, which establishes requirements for medical laboratories to demonstrate competence ... is already CLIA-licensed as well as College of American Pathologists (CAP)-accredited, a designation ...
(Date:1/24/2019)... ... 23, 2019 , ... rHEALTH LLC, an innovative digital health ... the United States Patent and Trademark Office (USPTO) for U.S. Patent Application No. ... This application covers the addition of a length scale to hydrogel microparticles. ...
Breaking Biology News(10 mins):
(Date:1/15/2019)... ... 15, 2019 , ... Personalized treatment plans may extend life expectancy for early-stage ... new study published in the journal Radiology. , Kidney, or renal, tumors are ... surgical procedure in which the tumor and part of the kidney are removed. However, ...
(Date:1/11/2019)... ... 11, 2019 , ... Drawing on over 22 years of software development expertise, ... EST will explore some of the key lessons that have driven customer satisfaction with ... multiple vendors, and find out how to ensure that you continue to be able ...
(Date:1/10/2019)... (PRWEB) , ... January 08, 2019 , ... VGI Medical ... has become a leader in bringing innovation to the market including VerteLoc, CerLoc, SiJoin ... the facet joint by utilizing a unique patented dual geometric design to limit motion ...
(Date:1/7/2019)... ... 07, 2019 , ... Kainos Medicine Inc. today announced that ... code-named "KM-819." KM-819 is an orally active small molecule that is a ... , This Phase 1 randomized, double-blind, placebo-controlled dose-escalation study was to evaluate ...
Breaking Biology Technology:
Cached News: