Progress against sarcoma

University of Utah geneticists have engineered mice that can develop synovial sarcoma a significant early step toward developing new treatments for the aggressive, deadly cancer that most often kills teenagers and young adults.

The genetically engineered, cancer-stricken mice were used to determine that synovial sarcoma develops in muscle cell precursors known as myoblasts, the researchers report in the April issue of the journal Cancer Cell, which features the study on its cover.

The cancer once was thought to arise in synovium, the membrane lining joints like the knee and elbow. That idea fell from favor in recent years, and until now, scientists have not known in which cells the cancer originated.

The only way to develop a therapy that is specific for this cancer is to understand how it works, and the mouse gives you that possibility, says the studys leader, Mario R. Capecchi, distinguished professor and co-chair of human genetics at the University of Utah School of Medicine and an investigator with the Howard Hughes Medical Institute.

But as is the case with many basic research advances, Capecchi says a treatment for synovial sarcoma based on the new finding remains at least a decade away. Nevertheless, there also is a wider promise.

First you can design and evaluate new treatments for this specific cancer and, second, you can design therapy for sarcomas in general because they share many common features with synovial sarcoma, says the studys first author, Malay Haldar, a human genetics graduate student who works in Capecchis laboratory.

Other authors of the University of Utah study are oncologist Stephen L. Lessnick, an assistant professor of pediatrics; Jeffrey D. Hancock, a fellow in pediatric hematology-oncology; and physician Cheryl Coffin, professor and head of pediatric pathology.

Broken and Fused Genes Trigger Synovial Sarcoma

Soft-tissue sarcomas are a gro

Contact: Lee Siegel
University of Utah Health Sciences Center

Page: 1 2 3 4

Related biology news :

1. Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
2. Progress toward a targeted therapy for a specific form of leukemia
3. Progress toward artificial photosynthesis?
4. 2nd annual Albert Szent-Gyrgyi Prize for Progress in Cancer Research awarded to Webster K. Cavenee
5. Progress in battle against life-threatening acute allergy
6. Progress report on Homogeneous Assay project
7. Progress being made in exploring potential use of stem cells to treat heart disease
8. Media Invite: Dinner to award prize for Progress in Cancer Research
9. Progress needed on global regime for access to genetic resources and benefit-sharing
10. Albert Szent-Gyrgyi Prize for Progress in Cancer Research announced
11. Progress toward a new remedy for chronic urinary tract infections?

Post Your Comments:

(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life ... for the life sciences and healthcare industries, announces a presentation by Subbu Viswanathan ... The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary ...
(Date:10/9/2017)... , ... October 09, 2017 , ... The award-winning American ... broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , ... faced with the challenge of how to continue to feed a growing nation. At ...
(Date:10/9/2017)... , ... October 09, 2017 ... ... on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® ... gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface ...
(Date:10/7/2017)... 6, 2017  The 2017 Nobel Prize in ... Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to broaden ... biology community. The winners worked with systems manufactured ... produce highly resolved, three-dimensional images of protein structures ...
Breaking Biology Technology:
Cached News: