Some people have allergic reactions to certain substances that can be so pronounced that they affect the entire body. Such a reaction − called anaphylaxis − can be so severe that it becomes life-threatening. An injection of adrenalin is currently the only effective remedy known for this condition. But adrenalin often has no, or insufficient, effect on the cardiovascular collapse that is a consequence of the allergic shock.
Anaphylaxis occurs fairly frequently and strikes up to 15% of the population. It can be caused by a bee sting, by medications, by contact with latex, or by certain foods such as peanuts. Because more and more people are being confronted with anaphylactic shock, and given the limitations of the current treatment methods, scientists are searching for better remedies.
Several leading actors
Scientists are aware of the possible role of PAF (Platelet Activating Factor) in blood pressure and heart disorders that result from shock like anaphylactic shock. They also know that extreme amounts of nitric oxide (NO) can lie at the basis of shock. The so-called NOS enzymes are responsible for the production of NO in the body. However, the role of NO in producing anaphylactic shock, or how shock is induced by PAF, has always been unclear. So, Anje Cauwels and her colleagues, under the leadership of Peter Brouckaert, have been focusing their attention on anaphylaxis to try to shed more light on these matters.
The mechanism exposed
The Ghent researchers used mice t
Contact: Joke Comijn
VIB, Flanders Interuniversity Institute of Biotechnology