HOME >> BIOLOGY >> NEWS
Progress in battle against life-threatening acute allergy

o study PAF and anaphylactic shock. To their great surprise, the hyper-acute PAF-induced shock was completely dependent on NO. Furthermore, the production of NO was not regulated by iNOS (the expected activator) but by the constitutive eNOS, which is activated via the PI3K pathway. Up to now, scientists have thought that this pathway only plays a role in normal blood pressure regulation, and not in shock.

The research team then set out to verify whether inhibition of the several leading actors could prevent anaphylactic shock. And indeed, from their research it turns out that inhibition of eNOS or PI3K provides total protection.

New perspectives for future therapies
The research of Cauwels and Brouckaert has yielded an unexpected new finding: namely, that eNOS-derived NO plays a key role in anaphylactic shock. This discovery opens new perspectives for treatment − it's now clear that eNOS and PI3K are prime targets for new drugs against anaphylaxis.


'"/>

Contact: Joke Comijn
info@vib.be
329-244-6611
VIB, Flanders Interuniversity Institute of Biotechnology
2-Aug-2006


Page: 1 2

Related biology news :

1. Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
2. Progress toward a targeted therapy for a specific form of leukemia
3. Progress against sarcoma
4. Progress toward artificial photosynthesis?
5. 2nd annual Albert Szent-Gyrgyi Prize for Progress in Cancer Research awarded to Webster K. Cavenee
6. Progress report on Homogeneous Assay project
7. Progress being made in exploring potential use of stem cells to treat heart disease
8. Media Invite: Dinner to award prize for Progress in Cancer Research
9. Progress needed on global regime for access to genetic resources and benefit-sharing
10. Albert Szent-Gyrgyi Prize for Progress in Cancer Research announced
11. Progress toward a new remedy for chronic urinary tract infections?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... ... communications and collaboration solutions, was present at Microsoft Ignite 2018, in Orlando, Florida, ... solutions. , Microsoft issued a statement about the new direction of Skype for ...
(Date:10/5/2018)... ... 2018 , ... EDETEK, the premier provider of digital clinical trial platforms, today ... MD on October 8-12, 2018. EDETEK is also a Gold Sponsor of the Bay-area ... , CDISC Interchanges are global events held annually on three continents with hundreds of ...
(Date:10/5/2018)... SAN DIEGO (PRWEB) , ... October 04, 2018 , ... ... team-building cooking classes have become so popular. , Cooking appeals to companies ... such as group interaction, team cohesion, collaboration and decision-making skills. It’s also appealing ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... ... September 28, 2018 , ... ... to increase the availability of the GlycoMark test, the only FDA-cleared blood test ... the partnership, PMLS will promote and offer the GlycoMark test to its network ...
(Date:9/27/2018)... ... September 26, 2018 , ... NDA Partners Chairman ... quality, regulatory, and in vitro diagnostic device expert with more than 28 years ... the firm as an Expert Consultant. Her experience includes leadership roles in regulatory ...
(Date:9/27/2018)... ... September 26, 2018 , ... Medable was ... aims to build the first human digitome, a digital representation of human health ... a seamless integration of all data sources. Dr. Michelle Longmire, Co-Founder and CEO ...
(Date:9/27/2018)... ... 27, 2018 , ... This past weekend at the TB ... Inc. announced they will formally merge companies and integrate their technologies to create ... other diseases. These two social enterprise corporations, both of which focus heavily on ...
Breaking Biology Technology:
Cached News: