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Progress in battle against life-threatening acute allergy

o study PAF and anaphylactic shock. To their great surprise, the hyper-acute PAF-induced shock was completely dependent on NO. Furthermore, the production of NO was not regulated by iNOS (the expected activator) but by the constitutive eNOS, which is activated via the PI3K pathway. Up to now, scientists have thought that this pathway only plays a role in normal blood pressure regulation, and not in shock.

The research team then set out to verify whether inhibition of the several leading actors could prevent anaphylactic shock. And indeed, from their research it turns out that inhibition of eNOS or PI3K provides total protection.

New perspectives for future therapies
The research of Cauwels and Brouckaert has yielded an unexpected new finding: namely, that eNOS-derived NO plays a key role in anaphylactic shock. This discovery opens new perspectives for treatment − it's now clear that eNOS and PI3K are prime targets for new drugs against anaphylaxis.


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Contact: Joke Comijn
info@vib.be
329-244-6611
VIB, Flanders Interuniversity Institute of Biotechnology
2-Aug-2006


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