HOME >> BIOLOGY >> NEWS
Protection against cancer may begin during pregnancy

hat a significant portion of the total lifetime exposure to PAHs and other toxins, including PCBs and dioxins, is transmitted to the fetus across the placental barrier and during nursing.

In laboratory studies, researchers exposed pregnant mice to a single high dose of one PAH called dibenzopyrene, a potent carcinogen, and about 80 percent of their 100 offspring died early in life from an aggressive T-cell lymphoma. Of those that survived to the mouse-equivalent of middle age, 100 percent had lung tumors.

By comparison, in a group of pregnant mice given the same carcinogen but who also received the chemoprotective supplement Indole-3-carbinol, or I3C, deaths from lymphoma were cut in half, and the number of lung tumors later in life was significantly reduced.

"It's clear that in mice this supplement provided significant protection against lymphoma and, later on, lung cancer," Williams said. "It's also worth noting that none of the infant mice received the protective supplement later in their life, at any stage beyond breast feeding. The protective effect of the compound came solely from maternal intake during pregnancy and nursing, but lasted into the animal's middle age. This is somewhat remarkable."

Although lung cancer is the leading cause of cancer death in both men and women, it's also true that only about one smoker in 10 gets lung cancer. It's possible, researchers say, that dietary and other factors in addition to smoking may predispose some smokers to get cancer while others don't. That this process may begin with carcinogens crossing the placental boundary and might be affected by diet is an area that has not been adequately studied, Williams said. In this study, both the exposure to carcinogens and the levels of Indole-3-carbinol given to pregnant mice through supplements were higher than those that would ordinarily be found in the environment or a normal diet, researchers said.

The scientists do not recommend that pregna
'"/>

Contact: David Williams
david.williams@oregonstate.edu
541-737-3277
Oregon State University
21-Dec-2006


Page: 1 2 3

Related biology news :

1. Los Alamos National Laboratory making progress in Groundwater Protection Program
2. Science for long-term management of the Marine Life Protection Act
3. No evidence that widely prescribed statins protect against prostate cancer
4. New study suggests Concord grape juice may provide protection against breast cancer
5. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
6. Natures weapon against nerve agents
7. Mucins stand guard against gut infections
8. Malaria -- Effective insecticide-repellent synergy against mosquito vectors
9. Crystal structure enables tailoring of pharmaceuticals against asthma
10. Tumor painting revolutionizes fight against cancer
11. New research holds promise for protecting cancer patients against infertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... May 21, 2019 , ... Experiential tourism, a trend encompassing culinary ... the last several years. And according to a recent report by Skift, a ... In fact, more and more travelers are wanting their journeys to be authentic and ...
(Date:5/21/2019)... ... ... The ASGCT Clinical Trials Finder is a customizable search engine for ... curated daily from ClinicalTrials.gov ensures the most up-to-date and applicable listings anywhere in the ... the development of the ASGCT Clinical Trials Finder reviewed the relevance of ...
(Date:5/16/2019)... ... May 16, 2019 , ... SFC Fluidics, Inc. (SFC) has partnered ... and Discovery Partnership that was awarded to SFC Fluidics in 2018 by JDRF. , ... pancreas (AP) system for people with type 1 diabetes (T1D). By accelerating the development ...
Breaking Biology News(10 mins):
(Date:5/7/2019)... ... May 06, 2019 , ... "The new ... number of repositories being asked to store cellular products being used in ... contributors who are world leaders, who have shared their expertise in building and ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS , May ...
(Date:4/18/2019)... Mass. (PRWEB) , ... April 18, 2019 , ... ... fossil fuels, a research team that includes a chemical engineer at Worcester Polytechnic ... exotic microorganism that may make it possible to manufacture isobutanol and other biofuels ...
(Date:4/10/2019)... , ... April 10, 2019 ... ... regenerative medicine manufacturing technology leaders, have locked into multiple agreements to help ... Companies across the regenerative medicine industry, ranging from synthetic biology companies that ...
Breaking Biology Technology:
Cached News: