HOME >> BIOLOGY >> NEWS
Protein averts cell suicide but might contribute to cancer

COLUMBUS , Ohio -- Scientists have discovered how an unusual protein helps a cell bypass damage when making new DNA, thereby averting the cell's self-destruction.

But they also discovered that this protein, an enzyme called Dpo4, often makes errors when copying the genomic DNA sequence that later might cause the cell to become cancerous.

The findings by researchers with Ohio State University 's Comprehensive Cancer Center are described in two back-to-back papers in The Journal of Biological Chemistry.

"Unrepaired DNA damage presents a big roadblock for the DNA replication machinery, which cannot go around it," says Zucai Suo, assistant professor of biochemistry. "This damage will trigger cell death because the DNA is not replicated.

"This protein bypasses the damage and saves cells from self-destructing, but it is very error prone, which suggests that it may also play a role in cancer."

Dpo4 is one of a family of enzymes called Y-family DNA polymerases that were first discovered about 10 years ago and are only now becoming understood.

"These enzymes provide a survival mechanism for cells," says first author Kevin Fiala, a graduate student in Suo's laboratory. "They allow DNA replication to continue, so the cell doesn't die. But they don't repair the DNA damage that exists."

DNA damage is a routine problem for cells, Suo says. For example, every cell loses more than 10,000 DNA bases daily. Dedicated repair enzymes fix 80 percent or more of this damage, but the rest remains.

Cells use Y-family enzymes to bypass that remaining damage when making new DNA prior to cell division, thus forcing these enzymes to copy damaged DNA.

How these bypass enzymes work, however, isn't known. The Dpo4 protein used in this research comes from a microorganism. It is relatively easy to produce in large quantities and to study, and it is similar to one of the four such enzymes found in hum
'"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University
29-Mar-2007


Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein interactions targets for Huntington disease therapy
5. Protein enables discovery of quantum effect in photosynthesis
6. Protein found that slows hepatitis C growth in liver cells
7. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
8. Protein structures for the entire yeast proteome
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... ... October 11, 2018 , ... The American College of Medical Informatics (ACMI) ... RN, PhD, Director of the National Library of Medicine (NLM), during the Opening Session ... is taking place Nov. 3 – 7. , In honor of Morris F. Collen, ...
(Date:10/5/2018)... , ... October 04, 2018 , ... EDETEK, the premier ... at the CDISC U.S. Interchange in Bethesda, MD on October 8-12, 2018. EDETEK is ... City, CA on November 5-6, 2018. , CDISC Interchanges are global events held ...
(Date:10/2/2018)... ... October 02, 2018 , ... Stem Cell Innovations (SCI), a global network ... stem cell therapy, has launched the pre-sale for their ICO with participants ... that will connect patients and stem cell specialists around the world. , ...
Breaking Biology News(10 mins):
(Date:10/2/2018)... Calif. (PRWEB) , ... October 02, 2018 , ... ... Undetected or ignored, contamination endangers the reliability and reproducibility of experimental data. Each ... contamination. , In this educational webinar, which is sponsored by Eppendorf , ...
(Date:9/28/2018)... (PRWEB) , ... September 28, 2018 , ... ... virtual events for tech innovators, engineers, and scientists from around the world, is ... the National University of San Marcos, as the winner of the LabRoots Summer ...
(Date:9/27/2018)... LOS ANGELES (PRWEB) , ... September 26, 2018 ... ... medical device and biologics manufacturer, debuted its focus® Pedicle Screw System today at ... Convention Center, September 26-29. , The Nvision focus Pedicle Screw System, ...
(Date:9/22/2018)... and WESTMINSTER, Colo. (PRWEB) , ... ... ... and Flagship Biosciences are excited to announce a strategic venture. The synergistic ... digital pathology platform provides complimentary and comprehensive biomarker profiling to empower clinical ...
Breaking Biology Technology:
Cached News: