HOME >> BIOLOGY >> NEWS
Protein 'chatter' linked to cancer activation

Hamilton, ON. August 13, 2007 Scientists have found the existence of cross-talk between human chromosome ends and the protein complexes central to the stability of the entire human genome, a chat that contributes to cancer development.

The research, published today in Nature Structural & Molecular Biology, sheds new light on the pathology of three related but non-curable cancer-predisposed human disorders: ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome.

The proteins whose deficiency is responsible for these three human disorders have the job of ensuring that chromosome ends are maintained and protected, says Xu-Dong Zhu, assistant professor of biology and the lead author on the study. As we age, our chromosome ends become shorter. Individuals whose ends deteriorate faster are at a higher risk of developing cancer because short chromosome ends are a serious threat to the stability of our genome. When the genome becomes unstable, it puts our bodies at greater risk of cancer.

Zhu adds that patients with ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome experience an accelerated rate of loss of DNA from chromosome ends. We didnt know why this happens; now we have found that the communication link between these proteins and a protein crucial for maintenance of chromosome ends is either missing or nonfunctional in these patients.

Zhu further explains that lack of this cross talk in normal cells promotes short chromosome ends and as a result promotes cancer formation. A key difference between cancer cells and normal cells is that the former maintain their chromosome ends and have the unlimited potential to grow. Disruption of this communication in cancer cells induces shortening of chromosome ends and may restrict their potential to grow.

Zhu says that the discovery will help researchers understand the onset and progression of the
'"/>

Contact: Jane Christmas
chrisja@mcmaster.ca
905-525-9140 x27988
McMaster University
13-Aug-2007


Page: 1 2

Related biology news :

1. Coming soon -- Protein synthesis without amino acids?
2. Protein pulling -- Learning how proteins fold by pulling them apart
3. Protein interactions targets for Huntington disease therapy
4. Protein enables discovery of quantum effect in photosynthesis
5. Protein found that slows hepatitis C growth in liver cells
6. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
7. Protein averts cell suicide but might contribute to cancer
8. Protein structures for the entire yeast proteome
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... 2017 Research and Markets has announced the ... & Trends - Industry Forecast to 2025" report to their ... The Global ... CAGR of around 15.1% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... ... high-level conversations among healthcare industry stakeholders, the discussion surrounding the topic will continue ... May 15-18, 2017 in Los Angeles, Calif. Hosted by the Workgroup for Electronic ...
(Date:4/25/2017)... 2017 Providence -based ... novel immune-modulating technology to an undisclosed global pharmaceutical company, ... Tregitopes, pronounced TĀ·rejĀ·itopes, are a set of ... CEO Annie De Groot and EpiVax ... an autoimmune disease therapy, Tregitopes are capable of ...
(Date:4/24/2017)...  Dante Labs announced today the offer of whole genome ... While American individuals have been able to access WGS at ... WGS below EUR 1,000. The sequencing includes bioinformatics ... to make informed decisions about disease monitoring, prevention, nutrition, exercise, ... ...
(Date:4/21/2017)... ... 2017 , ... The AMA is happy to announce that $48,000 in scholarships ... The scholarships are created through funds donated by model aviation organizations and individuals, AMA ... the AMA Scholarship Committee, which is made up of model aviation pilots and enthusiasts. ...
Breaking Biology Technology:
Cached News: