HOME >> BIOLOGY >> NEWS
Protein 'chatter' linked to cancer activation

Hamilton, ON. August 13, 2007 Scientists have found the existence of cross-talk between human chromosome ends and the protein complexes central to the stability of the entire human genome, a chat that contributes to cancer development.

The research, published today in Nature Structural & Molecular Biology, sheds new light on the pathology of three related but non-curable cancer-predisposed human disorders: ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome.

The proteins whose deficiency is responsible for these three human disorders have the job of ensuring that chromosome ends are maintained and protected, says Xu-Dong Zhu, assistant professor of biology and the lead author on the study. As we age, our chromosome ends become shorter. Individuals whose ends deteriorate faster are at a higher risk of developing cancer because short chromosome ends are a serious threat to the stability of our genome. When the genome becomes unstable, it puts our bodies at greater risk of cancer.

Zhu adds that patients with ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome experience an accelerated rate of loss of DNA from chromosome ends. We didnt know why this happens; now we have found that the communication link between these proteins and a protein crucial for maintenance of chromosome ends is either missing or nonfunctional in these patients.

Zhu further explains that lack of this cross talk in normal cells promotes short chromosome ends and as a result promotes cancer formation. A key difference between cancer cells and normal cells is that the former maintain their chromosome ends and have the unlimited potential to grow. Disruption of this communication in cancer cells induces shortening of chromosome ends and may restrict their potential to grow.

Zhu says that the discovery will help researchers understand the onset and progression of the
'"/>

Contact: Jane Christmas
chrisja@mcmaster.ca
905-525-9140 x27988
McMaster University
13-Aug-2007


Page: 1 2

Related biology news :

1. Coming soon -- Protein synthesis without amino acids?
2. Protein pulling -- Learning how proteins fold by pulling them apart
3. Protein interactions targets for Huntington disease therapy
4. Protein enables discovery of quantum effect in photosynthesis
5. Protein found that slows hepatitis C growth in liver cells
6. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
7. Protein averts cell suicide but might contribute to cancer
8. Protein structures for the entire yeast proteome
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... ... April 17, 2019 , ... USDM Life Sciences (USDM) announces that Jay Crowley, ... solutions for Creating a Sustainable Global UDI Compliance Strategy at the European UDI Forum ... , What device manufacturers did to comply with the US FDA UDI ...
(Date:4/16/2019)... Texas (PRWEB) , ... April 16, 2019 , ... ... collaboration between employers and search firms with over $2 billion in placement fees ... with applicant tracking and employee onboarding platform, ExactHire. , This strategic relationship ...
(Date:4/16/2019)... (PRWEB) , ... April 16, 2019 , ... ... its featured speakers for two signature events: The 2019 ISPE Biopharmaceutical Manufacturing ... on 20–21 June. Taking place in one of the most influential bio ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... USDM ... capacity of life sciences organizations to accelerate innovation and maximize productivity, announces that ... the past 12 months. , USDM’s Cloud Assurance is a managed ...
(Date:4/9/2019)... (PRWEB) , ... April 09, 2019 , ... The ... incoming members of the Society's leadership team, including a new addition to the presidential ... five of their peers to join the Society's leadership team for a three-year term ...
(Date:4/8/2019)... ... 2019 , ... US Capital Global Securities , an affiliate of US ... the privately held pharmaceutical company, S1 Biopharma (“S1”). , S1 has a pipeline of ... sexual dysfunction disorder and is ready to begin phase 2b trials. In phase 2a ...
(Date:4/4/2019)... ... April 02, 2019 , ... Biomeme, Inc. , a ... latest field-ready solution for performing PCR, RT-PCR, qPCR, and Isothermal tests called ... Rosland Franklin, an English chemist and X-ray crystallographer who made significant contributions to ...
Breaking Biology Technology:
Cached News: