HOME >> BIOLOGY >> NEWS
Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Washington, DC -- Cancer researchers at Georgetown University Medical Center have taken a step towards understanding how and why a widely used chemotherapy drug works in patients with breast cancer.

In laboratory studies, the researchers isolated a protein, caveolin-1, showing that in breast cancer cells this protein can enhance cell death in response to the use of Taxol, one of two taxane chemotherapy drugs used to treat advanced breast and ovarian cancer. But in order to work, they found the protein needs to be "switched on," or phosphorylated. The results were reported in the current (February 23) issue of the Journal of Biological Chemistry.

Their finding suggests it may eventually be possible to test individual breast cancer patients for the status of such molecular markers as caveolin-1 in their tumors to determine the efficacy-to-toxicity ratio for Taxol, said the studys first author, postdoctoral fellow Ayesha Shajahan, Ph.D., of Lombardi Comprehensive Cancer Center at Georgetown.

"Because breast tumors are not all the same, it is important to know the cancers molecular makeup in order to increase the efficiency, and lower the toxicity, of chemotherapy drugs, and this work takes us some steps forward in this goal," she said. "It also offers insights into why some breast cancer cells can become resistant to therapeutic drugs."

Additionally, the study identifies caveolin-1 as a new molecular target for increasing the efficacy of taxanes, according to the studys lead investigator, Robert Clarke, Ph.D., D.Sc., a Professor of Oncology and Physiology & Biophysics. "This is important because the taxanes are active drugs in breast cancer, so now that we know caveolin-1 is a new mechanism to explain how these drugs kill breast cancer cells, we can potentially take advantage of that fact to improve these agents."

The taxanes are Taxol (also known as paclitaxel) and Taxotere (docetaxel). Taxol was originally deriv
'"/>

Contact: Laura Cavender
lsc6@georgetown.edu
202-687-5100
Georgetown University Medical Center
21-Feb-2007


Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein interactions targets for Huntington disease therapy
5. Protein enables discovery of quantum effect in photosynthesis
6. Protein found that slows hepatitis C growth in liver cells
7. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
8. Protein averts cell suicide but might contribute to cancer
9. Protein structures for the entire yeast proteome
10. Protein overexpression at heart of heart failure
11. Protein sciences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 17, 2019 , ... ... the Southeast, and its acclaimed pediatric urologists are among the professionals honored ... annual recognition signifies excellence among the country’s pediatric healthcare landscape. , Georgia ...
(Date:7/17/2019)... ... 2019 , ... Imagine using a simple, portable test to detect cancer before ... osteoporosis. For South Dakota School of Mines & Technology researcher Congzhou Wang, Ph.D., these ... our ability to monitor and prevent disease,” says Wang. , Wang, an assistant ...
(Date:7/9/2019)... (PRWEB) , ... July 09, 2019 , ... ... accepted Tx Genetic Research into its incubator program. The founder and CEO of ... to improve the lives of those suffering from epithelial connective tissue disorders. , ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... ... July 18, 2019 , ... World renowned two-time ... joining forces with California-based charity Coalition Duchenne for its 9th Annual Expedition Mt. ... awareness and funding for Duchenne muscular dystrophy and was founded by Sabahan Catherine ...
(Date:7/9/2019)... DES MOINES, Iowa (PRWEB) , ... July 08, 2019 , ... ... in Des Moines, Iowa, the National Corn Growers Association (NCGA) announced the ... unique technology to improve a product or process using field corn to produce biobased ...
(Date:6/18/2019)... , ... June 18, 2019 , ... Personalized Stem ... New Drug (IND) application to the FDA for use of a person’s own adipose-derived ... a treatment of osteoarthritis in the knee. This IND is the first of ...
(Date:6/11/2019)... ... June 11, 2019 , ... Mytonomy, ... a national leader in opioid treatment, announced today they are partnering to combat ... Mytonomy recently deployed its virtual care platform at the Mayo Clinic to drive ...
Breaking Biology Technology:
Cached News: