HOME >> BIOLOGY >> NEWS
Protein interactions targets for Huntington disease therapy

HOUSTON (May 11, 2007) -- The identification of more than 200 new proteins that interact with the mutated protein that causes Huntingtons disease opens the door to developing treatments for the fatal neurodegenerative disorder, said a Baylor College of Medicine researcher who took part in the work that appears online today in the journal Public Library of Science Genetics.

BCM scientists actually determined which proteins among the list of more than 200 identified at Buck Institute modify the effect of the Huntingtons protein. The Buck Institute is located in Novato, California.

Huntingtons disease is a devastating, fatal neurological disorder that affects an estimated 30,000 Americans. It is dominantly inherited, which means that if a person inherits a single copy of the gene from a parent, that person will develop the disease usually in middle age. Children born to parents who go on to develop Huntingtons disease have a 50:50 chance of having the disease themselves. Musician Woody Guthrie was among its best known sufferers.

Many of the proteins that interact with Huntingtons are modulators of its toxicity, said Dr. Juan Botas, associate professor of molecular and human genetics at BCM and a senior author of the paper. This could also be a way to look for and identify factors that modulate a number of proteins involved in other neurodegenerative disease.

Modulating means that the interacting protein affects the deadly symptoms caused by Huntingtons, he said. Some of the interactive proteins might cause a person to develop the disease later; others could actually make the symptoms appear earlier or to be more severe.

When you tinker with some of these genes, you find that some of them improve the symptoms. These could be potential therapeutic targets, said Botas. When you tinker with others, it makes the Huntingtons more aggressive. These might be ones that accelerate the age of disease onset. Not everyone with
'"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
10-May-2007


Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein enables discovery of quantum effect in photosynthesis
5. Protein found that slows hepatitis C growth in liver cells
6. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
7. Protein averts cell suicide but might contribute to cancer
8. Protein structures for the entire yeast proteome
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2019)... (PRWEB) , ... March 26, 2019 , ... Evan ... Greenberg Traurig, LLP , was a panelist at the National Academy of Sciences ... NAS’ Keck Center. Holden, a member of the firm’s award-winning Pharmaceutical, Medical Device ...
(Date:3/26/2019)... ... March 26, 2019 , ... Ms. Wein will be ... and services. In her position, Ms. Wein will also oversee Lifecycle’s social media ... and customer beneficial features as well as any other marketing efforts in print ...
(Date:3/25/2019)... ... March 25, 2019 , ... ... contract research organisation focused on advancing drug discovery, have announced a collaboration to ... Tissue clearing methods, which are essential to get a better view of complex ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... April 16, 2019 , ... On April 24th, ... the U.S. Army Center for Environmental Health Research (USACEHR), with an award for ... Blue Sources, a veteran-owned company located at the Frederick Innovative Technology Center, Inc. ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a ... million bench plant expansion to increase production of methylene malonate monomers and oligomers. ... construction of Sirrus’ full-scale production facility, which is scheduled to break ground in ...
(Date:4/10/2019)... ... April 10, 2019 , ... ... manufacturing technology leaders, have locked into multiple agreements to help companies advance ... the regenerative medicine industry, ranging from synthetic biology companies that are gene ...
(Date:4/9/2019)... Calif. (PRWEB) , ... April 09, 2019 , ... ... services firm focused on increasing the capacity of life sciences organizations to accelerate ... Cloud Assurance platform in the past 12 months. , USDM’s ...
Breaking Biology Technology:
Cached News: