Protein linked to growth of organs ...( e researchers report. In their experim...)

Protein linked to growth of organs and cancer

e researchers report. In their experiments, Pan and his colleagues show that the hippo phosphorylation cascade, by adding a phosphate group to the Yorkie protein, turns it off.

When the scientists engineered reduced levels of hippo and other proteins that keep Yorkie in check, Yorkie caused tissues to overgrow by prompting more cells to grow and fewer to die, the hallmarks of cancer.

Further experiments in the fruit fly that replaced Yorkie with YAP showed both proteins play similar roles, suggesting YAP might participate in a tumor-related pathway in mammals.

Pan is now trying to identify the signal that tells genes like hippo to turn on or off once an organ grows to the appropriate size. That signal could be harnessed for therapeutics against cancer.

The authors of the paper besides Pan are Shian Wu from Hopkins, and Jianbin Huang, Jose Barrera and Krista Matthews from UT Southwestern. The study was funded by the National Institutes of Health.

'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
11-Aug-2005

Page: 1 2
Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein interactions targets for Huntington disease therapy
5. Protein enables discovery of quantum effect in photosynthesis
6. Protein found that slows hepatitis C growth in liver cells
7. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
8. Protein averts cell suicide but might contribute to cancer
9. Protein structures for the entire yeast proteome
10. Protein overexpression at heart of heart failure
11. Protein sciences

Post Your Comments:

(Date:5/17/2013)... An international team of scientists ... and cell movement inside a living frog embryo in ... new method to advance biological research and the search ... University and the Karlsruher Institut fr Technologie in Germany, ... U.S. Department of Energy,s Argonne National Laboratory, released the ...

(Date:5/16/2013)... to predict the stability of today,s largest ice sheets in ... million years ago, for example when Earth was going ... of a high sea level due to ice sheet collapse ... think that if the world,s largest ice sheets collapsed in ... our modern, progressively warming world. , However, a new ...

(Date:5/16/2013)... so many sports players and athletes choose to wear ... to be published in Psychological Science , a ... it may have to do with their testosterone levels. ... Farrelly of the University of Sunderland and colleagues, demonstrated ... a competitive task had higher testosterone levels than other ...

Breaking Biology News(10 mins):New X-ray method shows how frog embryos could help thwart disease 2 World's biggest ice sheets likely more stable than previously believed 2 High-testosterone competitors more likely to choose red 2

[0] New X-ray method shows how frog embryos could help thwart disease [0] World's biggest ice sheets likely more stable than previously believed [0] High-testosterone competitors more likely to choose red

(Date:5/16/2013)... 16, 2013 The Stirling Ultracold ... Cooling, Inc., Athens, OH, USA, won the Outstanding New ... International Society for Biological and Environmental Repositories (ISBER) at ... to one product annually, recognizes the company’s development and ... freezer. The award was presented to Global Cooling’s ...

(Date:5/16/2013)... Oven Industries, Inc. has been an industry leader ... since 1964. Expertly designed, the proportional-integral-derivative PID temperature ... As one of the most commonly used ... feedback system, which helps minimize errors. With three-term control, ... process, using a control element, like a valve or ...

(Date:5/16/2013)... Ill. (PRWEB) May 16, 2013 ... and portable models, from Cole-Parmer is designed to ... enhanced line includes: , The new Cole-Parmer® ... true workhorses in the lab. They ensure a ... and plasma specimen separation. Their standard four-place swinging ...

(Date:5/16/2013)... Kitware , a leading ... new Phase II SBIR funding from the U.S. ... an open-source, high performance computing (HPC) simulation and ... researchers to select only the toolkits and applications ... or analysis tasks. , Manufacturers increasingly rely ...

Breaking Biology Technology:Stirling Ultracold Ultra-Low Freezer Wins 2013 Outstanding New Product Award at International Biorepository Conference, Sydney, Australia 2 New PID Temperature Controllers Announced by Oven Industries Inc. 2 Cole-Parmer Offers Enhanced Selection of Centrifuges 2 Kitware Develops a Customizable Simulation Framework to Provide HPC for Small to Mid-Sized Manufacturers 2

[0] Stirling Ultracold Ultra-Low Freezer Wins 2013 Outstanding New Product Award at International Biorepository Conference, Sydney, Australia [0] New PID Temperature Controllers Announced by Oven Industries Inc.[0] Cole-Parmer Offers Enhanced Selection of Centrifuges [0] Kitware Develops a Customizable Simulation Framework to Provide HPC for Small to Mid-Sized Manufacturers

Cached News:

Tufts' David Walt named Howard Hughes Medical Institute Professor Salk scientist Ron Evans wins 2006 Gairdner Award for his discovery of hormone sensors Newly found species fills evolutionary gap between fish and land animals Hepatitis C therapy: Inhibiting newly discovered microDNA molecule

HHMI commits more than $30 million to help reverse brain drain, beat infectious diseases Society of Nuclear Medicine's 51st Annual Meeting June 19-23, 2004 Genetic screening study at Stanford ID's most aggressive adult leukemia strains Grant from GE Foundation to University of Houston to strengthen math, tech 'pipeline'