HOME >> BIOLOGY >> NEWS
Protein pulling -- Learning how proteins fold by pulling them apart

HOUSTON, July 19, 2007 -- Rice University physicists have unveiled an innovative way of finding out how proteins get their shape based on how they unfold when pulled apart. The experimental method could be of widespread use in the field of protein folding science, which has grown dramatically in the past decade, due in part to the discovery that misfolded proteins play a key role in diseases like Alzheimer's and Parkinson's.

Rice's new findings, which were three years in the making, are available online and slated to appear in an upcoming issue of Physical Review Letters. The article describes a new method scientists can use to map out exactly how much free energy is required throughout the folding process.

"We believe the method can be applied to any protein," said lead author Ching-Hwa Kiang, assistant professor of physics and astronomy. "Many people are working on this problem, and when we present our work at scientific conferences it often creates a good deal of excitement."

If DNA is the blueprint for life, then proteins are the machines built from those blueprints. All living cells produce proteins by stringing together strands of amino acids based on the sequences of their DNA. Proteins are created in linear chains, like strands of pearls, with each amino acid representing a bead on the strand. However, knowing the order of the amino acids in the strand gives no clue about how a protein functions. That's because every protein folds into a three-dimensional shape within about one second of being made, and it is this shape that dictates the protein's function.

By studying how much free energy it takes for a protein to fold into its final shape, scientists hope to learn more about how amino acid sequences affect protein function and how folding goes awry, as with some diseases.

At the halfway point between it's folded and unfolded state, a protein is like a rollercoaster balanced at the crest of the highest hi
'"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
19-Jul-2007


Page: 1 2 3

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein interactions targets for Huntington disease therapy
4. Protein enables discovery of quantum effect in photosynthesis
5. Protein found that slows hepatitis C growth in liver cells
6. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
7. Protein averts cell suicide but might contribute to cancer
8. Protein structures for the entire yeast proteome
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... ... September 30, 2019 , ... ... the capacity of life science organizations to accelerate innovation and maximize productivity, announces ... October 4th. , What: Just 30 days to 21 CFR Part 11 compliance ...
(Date:9/25/2019)... (PRWEB) , ... September 25, 2019 , ... ... in Austin, TX, have placed over 20,000 dental implants for a variety of ... highly technical zygomatic and pterygoid dental implants. Dental implants offer patients ...
(Date:9/24/2019)... ... September 23, 2019 , ... Global molecular diagnostics ... that Holotype HLA and other Omixon products will be featured among 10 posters ... for Histocompatibility and Immunogenetics (ASHI) in Pittsburgh, PA. Omixon’s Lunch Symposium on ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... ... latest research in the area of high-level X-ray methods using synchrotron-produced X-rays ... COO of Improved Pharma, will present “Synchrotron X-Ray Diffraction and Pair Distribution ...
(Date:9/24/2019)... , ... September 24, 2019 , ... ... Hannah Holscher, PhD, RD, to its Scientific Advisory Board. Dr. Holscher is an ... and the Division of Nutritional Sciences at the University of Illinois Urbana-Champaign, where ...
(Date:9/17/2019)... ... September 17, 2019 , ... Tucker, a Labrador retriever, was just a ... Tucker was limping and lame on his right hip and elbow. At one year ... called “the worst case the vet had seen.” He was prescribed pain medications, both ...
(Date:9/17/2019)... ... September 16, 2019 , ... ... CNBC on Saturday, September 21st @11:00am ET. Check local listings for more information ... (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to developing advanced ...
Breaking Biology Technology:
Cached News: