HOME >> BIOLOGY >> NEWS
Protein receptor cools passion of 'kiss and run' nerve cells

A new subtlety in the process of how the body's nervous system relays information may hinge on how "wet" the "kiss" is when one neuron fires a packet of neurotransmitter across a synapse to a receptive nerve cell.

A team of neuroscientists led by University of Illinois at Chicago biology professor Simon Alford report the finding in the March 14 issue of the Proceedings of the National Academy of Sciences.

"Until recently, the neuroscience field was solidly behind the idea that these little packets, or vesicles, either released all or none of their neurotransmitter into the synaptic cleft," said Alford. "We've identified a specific molecular mechanism that targets the machinery that causes the fusion process and found that instead of an all-or-none release, the vesicle just kisses the cell's presynaptic membrane. Neuroscientists call it 'kiss and run.' When it does it, our lab has now shown that only a little bit of neurotransmitter is released.

"This is important for the cell because it implies that we can change the degree of information that's passed through the synapse every time it's fired," said Alford.

The process involves a receptor protein on a pre-synaptic nerve cell -- the side that fires the packet of neurotransmitter -- that is affected by 5-hydroxytryptamine, or 5-HT, a body chemical often associated with mood. When 5-HT binds to this cell receptor, it activates something called a G protein that is made of two subunits -- one called alpha, the other beta-gamma. When these subunits are released, they activate the next step in a chain of events that move signal information through the nerve cell.

Alford's lab previously discovered that the beta-gamma subunit affects the molecular machinery that causes release of neurotransmitter -- the amino acid glutamate.

"It's very fast," said Alford. "You turn on a G protein, and it immediately targets the mechanism to modify release."

On the receiving cell, the
'"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
6-Mar-2006


Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein interactions targets for Huntington disease therapy
5. Protein enables discovery of quantum effect in photosynthesis
6. Protein found that slows hepatitis C growth in liver cells
7. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
8. Protein averts cell suicide but might contribute to cancer
9. Protein structures for the entire yeast proteome
10. Protein overexpression at heart of heart failure
11. Protein sciences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... , ... August 11, 2020 , ... ... based in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI ... Both Roche and J&J have annual Research and Development spending in excess ...
(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... to participate in the prestigious National STEM Scholar Program, a unique professional development ... building, and project support for middle school science teachers nationwide. , Created in ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, ... contract awarded by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) ... develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Texas (PRWEB) , ... July 29, 2020 , ... ... solutions today announced the launch of its new tagline, “BUILDING FOR LIFE.” The ... biopharmaceutical industry and around the globe, requiring fast track capacity to provide patients ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and ... a great surgery is only the beginning of a successful study, while protecting and ... Join Brad Gien, Global Head of Surgery from Envigo in a ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
Breaking Biology Technology:
Cached News: