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Protein shown to rally biological clock

A biologist at Washington University in St. Louis and his collaborators have identified the factor in mammalian brain cells that keeps cells in synchrony so that functions like the wake-sleep cycle, hormone secretion and loco motor behaviors are coordinated daily over a 24-hour period.

Erik Herzog, Ph.D., Washington University associate professor of Biology in Arts & Sciences, Sara Aton, Ph.D., a graduate student in Herzogs lab who is now a postdoctoral researcher at the University of Pennsylvania, James Huettner, Ph.D., associate professor in cell biology and physiology at the Washington

University School of Medicine, and Martin Straume, a biostatistician, have determined that VIP vasoactive intestinal polypeptide is the rallying protein that signals the brains biological clock to coordinate daily rhythms in behavior and physiology.

The finding clarifies the roles that both VIP and a neurotransmitter GABA play in synchronizing biological clocks, and sheds light on how mammals, in this case mice and rats. regulate circadian rhythm. Results were published in the Nov. 27- Dec. 1 online issue of the Proceedings of the National Academy of Sciences.

Neurons in the biological clock, an area called the suprachiasmatic nucleus (SCN), located at the base of the brain right across the optic nerve, keep 24-hour time and are normally highly synchronized. The SCN is composed of 10,000 neurons on one side of the hypothalamus, and 10,000 on the other. Together these neurons are intrinsic clocks in communication with each other to keep 24-hour time.

It had been thought that GABA was the prime candidate for the rallying role. All SCN neurons make this inhibitory neurotransmitter, and it had been shown that giving GABA daily at 8 a.m. to SCN cells synchronizes them.

The surprise was that GABA was not needed, said Herzog. VIP synchronizes even when we block all GABA signaling. When we blocked GABA, synchrony was perfectly fine. Instead,
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Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
29-Nov-2006


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