HOME >> BIOLOGY >> NEWS
Protein structures for the entire yeast proteome

Imagine the power of knowing the three-dimensional structures of all proteins. The 3D-structure can provide information about critical protein-protein interactions both from a global perspective as well as all the way down to the level of minuscule molecular and biochemical detail. In much the same way, structural information can reveal a lot about the proteins evolutionary relationships and functions. Even to provide this information about all the proteins in one organismits proteomewould offer a more global view of these relationships, but solving each structure individually would be a formidable task.

However, in a new study published online this week in the open access journal PLoS Biology, Lars Malmstrm, David Baker, and colleagues have done precisely this for the model organism yeast. These researchers divided all Saccharomyces cerevisiae proteins into nearly 15,000 distinct domains (regions of a protein that fold into a distinct quaternary globular structure). They then applied their own de novo structure prediction methods together with worldwide distributed computing to predict three-dimensional structures for all domains lacking sequence similarity to proteins of known structure.

To overcome the uncertainties in de novo structure prediction, Lars Malmstrm and colleagues combined these predictions with data on the biological process, function, and localization of the proteins from previous experimental studies to assign the domains to families of evolutionarily related proteins. These genome-wide domain predictions and superfamily assignments provide the basis for the generation of experimentally testable hypotheses about the mechanism of action for a large number of yeast proteins.


'"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
19-Mar-2007


Page: 1

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein interactions targets for Huntington disease therapy
5. Protein enables discovery of quantum effect in photosynthesis
6. Protein found that slows hepatitis C growth in liver cells
7. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
8. Protein averts cell suicide but might contribute to cancer
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... , ... April 17, 2019 , ... ... biostatistics, and other services to clinical trial sponsors, has entered into a multi-year ... agreement will enable Quartesian, a member of Medrio’s Certified Partner Program, to leverage ...
(Date:4/16/2019)... Tenn. (PRWEB) , ... April 16, 2019 , ... ... tissue markets, celebrated the grand opening of its new medical device facility on ... 2005. , Located in Memphis, TN the new facility includes 108,500 square feet ...
(Date:4/16/2019)... NEW YORK (PRWEB) , ... April 16, 2019 ... ... the Top 50 Healthcare Technology CEOs of 2019 . An extensive process ... the fields of medical devices, biotech, healthcare analytics, healthcare software and other related ...
Breaking Biology News(10 mins):
(Date:3/27/2019)... , ... March 27, 2019 , ... In honor of ... awareness on the importance of healthy meals and good nutrition. This month, Chef ... Food Bank’s volunteer chef. , The first segment addressed the nutritional value ...
(Date:3/23/2019)... ... March 22, 2019 , ... ... LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary approach for the ... polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, and ...
(Date:3/19/2019)... ... ... Bogey was nine years old when he injured both of his cruciate ligaments. On ... Bogey to experience problems with his mobility. According to his owners, he could barely ... the couch. , His owners, devastated at the sight of Bogey in so much pain ...
(Date:3/19/2019)... , ... March 19, 2019 ... ... HaShomer, the largest hospital in Israel and the Middle East region, and ... the state-of-the-art Cocoon™ manufacturing platform. The partnership will enable Sheba to vastly ...
Breaking Biology Technology:
Cached News: