HOME >> BIOLOGY >> NEWS
Protein structures for the entire yeast proteome

Imagine the power of knowing the three-dimensional structures of all proteins. The 3D-structure can provide information about critical protein-protein interactions both from a global perspective as well as all the way down to the level of minuscule molecular and biochemical detail. In much the same way, structural information can reveal a lot about the proteins evolutionary relationships and functions. Even to provide this information about all the proteins in one organismits proteomewould offer a more global view of these relationships, but solving each structure individually would be a formidable task.

However, in a new study published online this week in the open access journal PLoS Biology, Lars Malmstrm, David Baker, and colleagues have done precisely this for the model organism yeast. These researchers divided all Saccharomyces cerevisiae proteins into nearly 15,000 distinct domains (regions of a protein that fold into a distinct quaternary globular structure). They then applied their own de novo structure prediction methods together with worldwide distributed computing to predict three-dimensional structures for all domains lacking sequence similarity to proteins of known structure.

To overcome the uncertainties in de novo structure prediction, Lars Malmstrm and colleagues combined these predictions with data on the biological process, function, and localization of the proteins from previous experimental studies to assign the domains to families of evolutionarily related proteins. These genome-wide domain predictions and superfamily assignments provide the basis for the generation of experimentally testable hypotheses about the mechanism of action for a large number of yeast proteins.


'"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
19-Mar-2007


Page: 1

Related biology news :

1. Protein chatter linked to cancer activation
2. Coming soon -- Protein synthesis without amino acids?
3. Protein pulling -- Learning how proteins fold by pulling them apart
4. Protein interactions targets for Huntington disease therapy
5. Protein enables discovery of quantum effect in photosynthesis
6. Protein found that slows hepatitis C growth in liver cells
7. Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex
8. Protein averts cell suicide but might contribute to cancer
9. Protein overexpression at heart of heart failure
10. Protein sciences
11. Protein identified that regulates effectiveness of Taxol chemotherapy in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2018)... ... November 07, 2018 , ... Features such as ... to last-minute changes all contribute to client retention and referral business in the ... and expense services provider says 80 percent of its new business is attributed ...
(Date:11/7/2018)... ... November 07, 2018 , ... The awards were presented by ... industry. The event was attended by 150 industry executives from leading life science ... discovery. The winners were determined by responses to an online ballot completed by ...
(Date:11/3/2018)... ... November 01, 2018 , ... The ... to be held February 6-8, 2019 at the Crowne Plaza Times Square in ... Biomarker plenary session is Genentech’s Global Franchise Leader in Cancer Immunotherapy Biomarkers and ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... 13, 2018 , ... Sharon Kleyne, founder and new water ... Oregon believes in the power of talk radio education Power of Water® research ... Power of Water® on talk radio every week with the “Sharon Kleyne Hour”, ...
(Date:11/9/2018)... and PHILADELPHIA (PRWEB) , ... November 08, 2018 ... ... control system integrator of custom industrial automation and IT solutions with 140 employees ... exhibiting at Automation Fair®, taking place at the Pennsylvania Convention Center on November ...
(Date:11/5/2018)... ... November 05, 2018 , ... Frederick National Laboratory for Cancer ... to science research and education in the Frederick County area. , Frederick ... access to STEM-based undergraduate and graduate degree and certificate programs offered by partnering ...
(Date:11/3/2018)... , ... November 01, 2018 , ... ... Champion Consortium Summit. Dr. Jean Mulinde, Senior Advisor, Division of Clinical Compliance Evaluation, ... monitor safety and ensure data reliability. , What should clinical research industry stakeholders ...
Breaking Biology Technology:
Cached News: